{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:43:35Z","timestamp":1790725415388,"version":"4.1.0"},"reference-count":30,"publisher":"King Faisal Specialist Hospital and Research Centre","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Saudi Med"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Postoperative complications of colorectal cancer surgery contribute to increased morbidity and mortality in patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>OBJECTIVES:<\/jats:title>\n            <jats:p>Investigate the role of biochemical markers in serum and peritoneal fluid in the development of postoperative complications in patients with enteral anastomosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>DESIGN:<\/jats:title>\n            <jats:p>Prospective.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>SETTING:<\/jats:title>\n            <jats:p>University hospitals.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>PATIENTS AND METHODS:<\/jats:title>\n            <jats:p>\n              The studied population consisted of patients who underwent surgical treatment with created anastomosis or Hartmann's resection from April 2022 to April 2024, conducted at the Clinical-Hospital Center Kosovska Mitrovica and the University Clinical Center Kragujevac. Spearman's correlation coefficient (r\n              <jats:sub>s<\/jats:sub>\n              ) was used to test associations between categorical variables.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>MAIN OUTCOME MEASURES:<\/jats:title>\n            <jats:p>Lactate, albumin, lactate dehydrogenase, and IgA antibodies were monitored as predictors of anastomotic dehiscence and general postoperative complications.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>SAMPLE SIZE:<\/jats:title>\n            <jats:p>52<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              The concentration of lactate in the drain fluid on the third postoperative day was statistically significantly higher in patients who did not develop anastomotic dehiscence (\n              <jats:italic>P<\/jats:italic>\n              =.006). The concentration of IgA antibodies in the drain fluid on the third and fifth days post-surgery showed a moderate negative correlation with lactate concentration (r\n              <jats:sub>s<\/jats:sub>\n              =-.670,\n              <jats:italic>P<\/jats:italic>\n              =.012; r\n              <jats:sub>s<\/jats:sub>\n              =-.577,\n              <jats:italic>P<\/jats:italic>\n              =.039), repectively. There was a significantly higher concentration of albumin in the drain fluid on the third day post-surgery in patients who developed dehiscence (\n              <jats:italic>P<\/jats:italic>\n              =.040), and on the seventh day post-surgery in those who did not develop dehiscence (\n              <jats:italic>P<\/jats:italic>\n              =.001). The concentration of LDH on the third day in the drain fluid after surgery was statistically significantly higher in patients who did not develop dehiscence (\n              <jats:italic>P<\/jats:italic>\n              =.020). There was a statistically significant difference in lactate concentration in the drain fluid on the third (\n              <jats:italic>P<\/jats:italic>\n              &lt;.001) and fifth days (\n              <jats:italic>P<\/jats:italic>\n              =.041) post-surgery, as well as in albumin concentration on the third day post-surgery (\n              <jats:italic>P<\/jats:italic>\n              =.024) with respect to the development of general postoperative complications.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION:<\/jats:title>\n            <jats:p>This study revealed significant differences in the concentrations of lactate, albumin, and LDH in the drain fluid on the third and fifth days post-surgery with respect to the development of complications. These results suggest that monitoring these markers may help in the early identification of patients at risk of complications such as dehiscence.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>LIMITATIONS:<\/jats:title>\n            <jats:p>Limited literature on specific aspects of this study, including the absence of a control group, small sample size, and two-center study.<\/jats:p>\n          <\/jats:sec>","DOI":"10.5144\/0256-4947.2024.422","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T14:09:56Z","timestamp":1733753396000},"page":"422-434","source":"Crossref","is-referenced-by-count":2,"title":["Prospective evaluation of serum and peritoneal fluid markers as indicators of postoperative complications in patients with enteric anastomosis"],"prefix":"10.5144","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6634-1380","authenticated-orcid":true,"given":"Mladen","family":"Kasalovi\u0107","sequence":"first","affiliation":[{"name":"From the Surgical Clinic, Clinical Hospital Center Kosovska Mitrovica, Kosovska Mitrovica, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo\u017eidar","family":"Odalovi\u0107","sequence":"additional","affiliation":[{"name":"From the Department of Surgery, Faculty of Medicine, University of Pri\u0161tina, Kosovska Mitrovica, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lazar","family":"Mihajlovi\u0107","sequence":"additional","affiliation":[{"name":"From the Surgical Clinic, University Clinical Center Kragujevac, Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Jakovljevi\u0107","sequence":"additional","affiliation":[{"name":"From the Surgical Clinic, University Clinical Center Kragujevac, Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zlatan","family":"Elek","sequence":"additional","affiliation":[{"name":"From the Department of Surgery, Faculty of Medicine, University of Pri\u0161tina, Kosovska Mitrovica, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gojko","family":"Igrutinovi\u0107","sequence":"additional","affiliation":[{"name":"From the Department of Surgery, Faculty of Medicine, University of Pri\u0161tina, Kosovska Mitrovica, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"An\u0111elkovi\u0107","sequence":"additional","affiliation":[{"name":"From the Laboratory Diagnostics Service, Clinical Hospital Center, Kosovska Mitrovica, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjana","family":"Paj\u010din","sequence":"additional","affiliation":[{"name":"From the Faculty of Medicine, University of Pristina, Medical Statistics and Informatics, Kosovska Mitrovica, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3134","reference":[{"key":"e_1_3_2_2_2","volume-title":"C-reaktivni protein i matriksna metaloproteinaza-9 u peritoneumskoj drena\u017enoj te\u010dnosti kao rani pokazatelji postoperativnih komplikacija kod bolesnika operisanih zbog kolorektalnog karcinoma","author":"Kosti\u0107 Z","year":"2014","unstructured":"Kosti\u0107 Z. 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