{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:52:43Z","timestamp":1793083963284,"version":"4.5.0"},"reference-count":86,"publisher":"King Faisal Specialist Hospital and Research Centre","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Saudi Med"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>\n              <jats:italic toggle=\"yes\">Candida (Candidozyma) auris<\/jats:italic>\n              is a high priority fungal pathogen due to its antifungal resistance and its association with increased morbidity and mortality in infected patients.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>OBJECTIVES:<\/jats:title>\n            <jats:p>\n              The aim of this study was to identify Candida species in clinical samples and to determine the clades and in vitro antifungal resistance of\n              <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n              .\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>DESIGN:<\/jats:title>\n            <jats:p>Retrospective cohort<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>SETTINGS:<\/jats:title>\n            <jats:p>Single-center tertiary hospital in T\u00fcrkiye<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>MATERIAL AND METHODS:<\/jats:title>\n            <jats:p>\n              The study was conducted in the Medical Microbiology Laboratory of \u00dcmraniye Training and Research Hospital between December 2023 and October 2024. Fungal samples were identified using bio-M\u00e9rieux VITEK MS v.3.2 (bio-M\u00e9rieux, France) and RT-PCR. Antifungal susceptibility testing of\n              <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n              was performed by VITEK 2 Compact AST YS08 and SYO.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>MAIN OUTCOME MEASURES:<\/jats:title>\n            <jats:p>\n              Identification of Candida species, in-vitro antifungal resistance of\n              <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>SAMPLE SIZE:<\/jats:title>\n            <jats:p>846 fungal isolates obtained from 746 patients were included.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              A total of 846 fungal isolates were identified, with\n              <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n              being the most common (n=440, 52%), followed by\n              <jats:italic toggle=\"yes\">Nakaseomyces glabratus<\/jats:italic>\n              (n=124, 14.7%),\n              <jats:italic toggle=\"yes\">C. parapsilosis<\/jats:italic>\n              (n=85, 10.1%),\n              <jats:italic toggle=\"yes\">C. tropicalis<\/jats:italic>\n              (n=69, 8.2%) and\n              <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n              (n=57, 6.7%). All\n              <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n              isolates were susceptible to anidulafungin. Of these isolates, 47 (82%) were resistant to fluconazole, 34 (60%) to amphotericin B, four (7%) to caspofungin and three (5%) to micafungin. One isolate was resistant to amphotericin B, fluconazole, caspofungin and micafungin. A total of 31 (54%) isolates were resistant to amphotericin B and fluconazole. In accordance with the manufacturer's recommendations, 57 isolates were evaluated as Clade-1.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION:<\/jats:title>\n            <jats:p>\n              <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n              infections are becoming increasingly common. In order to better understand antifungal-resistance of this pathogen, advanced methods should be used for rapid detection of clades and mutations in the FKS gene should be revealed.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>LIMITATIONS:<\/jats:title>\n            <jats:p>Single center, whole genome sequence analysis were not performed.<\/jats:p>\n          <\/jats:sec>","DOI":"10.5144\/0256-4947.2025.207","type":"journal-article","created":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T06:14:46Z","timestamp":1754201686000},"page":"207-217","source":"Crossref","is-referenced-by-count":7,"title":["Identification and antifungal resistance profiling of\n            <i>Candida (Candidozyma) auris<\/i>\n            in a tertiary hospital in Istanbul, T\u00fcrkiye"],"prefix":"10.5144","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1297-944X","authenticated-orcid":true,"given":"Y\u00fcksel","family":"Akkaya","sequence":"first","affiliation":[{"name":"From the Department of Medical Microbiology, Faculty of Medicine, University of Health Sciences Hamidiye, Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beg\u00fcm Nal\u00e7a","family":"Erdin","sequence":"additional","affiliation":[{"name":"From the Department of Medical Microbiology, \u00dcmraniye E\u011fitim Ve Ara\u015ft\u0131rma Hastanesi, Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet M\u00fcnir","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"From the Department of Emergency Medicine, Ministry of Health, Abdulkadir Yuksel State Hospital, Gaziantep, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130brahim Halil","family":"K\u0131l\u0131\u00e7","sequence":"additional","affiliation":[{"name":"From the Department of Molecular Biology, Faculty of Arts and Sciences, Gaziantep University, Gaziantep, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z\u00fclal A\u015f\u00e7\u0131","family":"Toraman","sequence":"additional","affiliation":[{"name":"From the Department of Medical Microbiology, Faculty of Medicine, Firat University, Elazig, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3134","reference":[{"issue":"5","key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"927","DOI":"10.3390\/microorganisms12050927","article-title":"Candida auris outbreaks: current status and future perspectives","volume":"12","author":"Gaetano S","year":"2024","unstructured":"Gaetano S, Midiri A, Mancuso G, Biondo C, Avola MG. 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