{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:35:28Z","timestamp":1787841328637,"version":"build-2784847793"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T00:00:00Z","timestamp":1404950400000},"content-version":"vor","delay-in-days":1105,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>We report a case of a 61-year-old man with a history of CREST syndrome (calcinosis cutis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia) who presented for evaluation of thrombocytopenia. He had evident cervical adenopathy and lymph node biopsy showed small lymphocytic lymphoma (SLL) with evident systemic adenopathy and bone marrow involvement. The patient achieved a complete remission with FCR (fludarabine\/cyclophosphamide\/rituximab) chemotherapy. About 30 cases of lymphomas are reported in the literature in association with systemic sclerosis. To our knowledge, there are no reports of a small lymphocytic lymphoma (SLL) in association with limited cutaneous systemic sclerosis with classic features of the CREST syndrome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5144\/1658-3876.2011.132","type":"journal-article","created":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T11:43:15Z","timestamp":1405510995000},"page":"132-135","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Small lymphocytic lymphoma in a patient with CREST syndrome"],"prefix":"10.4103","volume":"4","author":[{"given":"Basem M.","family":"William","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey","family":"Harbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apar K.","family":"Ganti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Bierman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"2","key":"10.5144\/1658-3876.2011.132_bb0005","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1365-2796.1993.tb00719.x","article-title":"Scleroderma--clinical aspects","volume":"234","author":"Black","year":"1993","journal-title":"J intern Med"},{"issue":"2","key":"10.5144\/1658-3876.2011.132_bb0010","first-page":"202","article-title":"Scleroderma (systemic sclerosis): classification, subsets and pathogenesis","volume":"15","author":"LeRoy","year":"1998","journal-title":"J Rheumatol."},{"issue":"4","key":"10.5144\/1658-3876.2011.132_bb0015","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/art.1780360405","article-title":"Cancer in systemic sclerosis","volume":"36","author":"Abu-Shakra","year":"1993","journal-title":"Arthritis Rheum"},{"key":"10.5144\/1658-3876.2011.132_bb0020","first-page":"1113","article-title":"A cohort study of cancer incidence in systemic sclerosis","volume":"33","author":"Derk","year":"2006","journal-title":"J Rheumatol"},{"issue":"8","key":"10.5144\/1658-3876.2011.132_bb0025","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1001\/archderm.1979.04010080014013","article-title":"Cancer and scleroderma","volume":"115","author":"Duncan","year":"1979","journal-title":"Arch Dermatol"},{"issue":"8","key":"10.5144\/1658-3876.2011.132_bb0030","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1136\/ard.62.8.728","article-title":"Risk of cancer in patients with scleroderma: a population based cohort study","volume":"62","author":"Hill","year":"2003","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"10.5144\/1658-3876.2011.132_bb0035","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1136\/ard.52.7.531","article-title":"Scleroderma and malignancy: an epidemiological study","volume":"52","author":"Rosenthal","year":"1993","journal-title":"Ann Rheum Dis"},{"issue":"12","key":"10.5144\/1658-3876.2011.132_bb0040","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1002\/art.1780281204","article-title":"Cancer and systemic sclerosis","volume":"28","author":"Roumm","year":"1985","journal-title":"An epidemiologic study. Arthritis Rheum."},{"issue":"5","key":"10.5144\/1658-3876.2011.132_bb0045","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0248-8663(05)80845-8","article-title":"Systemic scleroderma and malignant diseases. A review of the literature","volume":"12","author":"Bielefeld","year":"1991","journal-title":"Rev Med Interne"},{"issue":"Suppl 1","key":"10.5144\/1658-3876.2011.132_bb0050","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/10428190802311425","article-title":"Epidemiology, pathology and treatment of non-follicular indolent lympho-mas","volume":"49","author":"Landgren","year":"2008","journal-title":"Leuk Lymphoma"},{"issue":"12","key":"10.5144\/1658-3876.2011.132_bb0055","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1200\/JCO.1999.17.12.3835","article-title":"World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997","volume":"17","author":"Harris","year":"1999","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.5144\/1658-3876.2011.132_bb0060","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1182\/blood.V46.2.219.219","article-title":"Clinical staging of chronic lymphocytic leukemia","volume":"46","author":"Rai","year":"1975","journal-title":"Blood"},{"issue":"1","key":"10.5144\/1658-3876.2011.132_bb0065","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0.CO;2-V","article-title":"A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis","volume":"48","author":"Binet","year":"1981","journal-title":"Cancer"},{"issue":"12","key":"10.5144\/1658-3876.2011.132_bb0070","doi-asserted-by":"crossref","first-page":"5446","DOI":"10.1182\/blood-2007-06-093906","article-title":"Guidelines for the diagnosis and treatment of chronic lymphocyt-ic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines","volume":"111","author":"Hallek","year":"2008","journal-title":"Blood"},{"issue":"29","key":"10.5144\/1658-3876.2011.132_bb0075","doi-asserted-by":"crossref","first-page":"4648","DOI":"10.1200\/JCO.2006.09.4508","article-title":"Assessment of chronic lymphocytic leukemia and small lymphocytic lymphoma by absolute lymphocyte counts in 2,126 patients: 20 years of experience at the University of Texas M.D. Anderson Cancer Center","volume":"25","author":"Tsimberidou","year":"2007","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.5144\/1658-3876.2011.132_bb0080","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/SMJ.0b013e31815838ce","article-title":"Systemic sclerosis and malignancy: a review of the literature","volume":"101","author":"Wooten","year":"2008","journal-title":"South Med J"},{"issue":"1","key":"10.5144\/1658-3876.2011.132_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10067-009-1286-9","article-title":"Non-Hodgkin\u2019s lymphoma in systemic sclerosis: case and literature review","volume":"29","author":"Vettori","year":"2010","journal-title":"Clin Rheu-matol"},{"issue":"1","key":"10.5144\/1658-3876.2011.132_bb0090","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jbspin.2005.01.009","article-title":"Systemic sclerosis and gastric MALT lymphoma","volume":"73","author":"Arnaud","year":"2006","journal-title":"Joint Bone Spine"},{"issue":"3","key":"10.5144\/1658-3876.2011.132_bb0095","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1600-0609.1997.tb00975.x","article-title":"Lymphoma and systemic sclerosis\u2212an uncommon association or possible coincidence of two disorders with a fatal outcome","volume":"59","author":"Haviv","year":"1997","journal-title":"Eur J Haematol"},{"issue":"11","key":"10.5144\/1658-3876.2011.132_bb0100","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1097\/00007611-197911000-00034","article-title":"Pemphigus vulgaris and lymphoma in a patient with scleroderma","volume":"72","author":"Katz","year":"1979","journal-title":"South Med J"},{"issue":"1","key":"10.5144\/1658-3876.2011.132_bb0105","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s002770050200","article-title":"Multilobated B cell lymphoma (Pinkus variant) with isolated muscular localization in a patient with systemic sclerosis: a case report","volume":"73","author":"Parma","year":"1996","journal-title":"Ann Hematol"},{"issue":"4","key":"10.5144\/1658-3876.2011.132_bb0110","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s10067-004-0879-6","article-title":"Mucosa-associated lymphoid tissue lymphoma (MALT) of salivary glands and scleroderma: a case report","volume":"23","author":"Prochorec-Sobieszek","year":"2004","journal-title":"Clin Rheumatol"},{"issue":"1","key":"10.5144\/1658-3876.2011.132_bb0115","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0049-0172(99)80037-7","article-title":"Rheumatic syndromes: clues to occult neoplasia","volume":"29","author":"Naschitz","year":"1999","journal-title":"Semin Arthritis Rheum"},{"issue":"1","key":"10.5144\/1658-3876.2011.132_bb0120","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000018070","article-title":"Systemic sclerosis revealing T-cell lymphoma","volume":"198","author":"Hasegawa","year":"1999","journal-title":"Dermatology"},{"issue":"2","key":"10.5144\/1658-3876.2011.132_bb0125","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000086585","article-title":"Angioimmunoblastic T cell lym-phoma with an unusual proliferation of Epstein-Barr virus-associated large B cells arising in a patient with progressive systemic sclerosis","volume":"114","author":"Yamamoto","year":"2005","journal-title":"Acta Haematol"},{"issue":"7","key":"10.5144\/1658-3876.2011.132_bb0130","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0046-8177(94)90293-3","article-title":"Immunosuppression, autoimmunity, and lymphoproliferative disorders","volume":"25","author":"Frizzera","year":"1994","journal-title":"Hum Pathol"},{"issue":"6","key":"10.5144\/1658-3876.2011.132_bb0135","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1002\/art.20274","article-title":"Altered blood B lymphocyte homeostasis in systemic sclerosis: expanded naive B cells and diminished but activated memory B cells","volume":"50","author":"Sato","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"4","key":"10.5144\/1658-3876.2011.132_bb0140","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/j.0022-202X.2005.23767.x","article-title":"Abnormal natural killer cell function in systemic sclerosis: altered cytokine production and defective killing activity","volume":"125","author":"Horikawa","year":"2005","journal-title":"J Invest Dermatol"},{"issue":"4","key":"10.5144\/1658-3876.2011.132_bb0145","first-page":"665","article-title":"Malignancy in progressive systemic sclerosis\u2212association with breast carcinoma","volume":"10","author":"Lee","year":"1983","journal-title":"J Rheumatol"},{"issue":"6","key":"10.5144\/1658-3876.2011.132_bb0150","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1182\/blood.V85.6.1580.bloodjournal8561580","article-title":"p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias","volume":"85","author":"Dohner","year":"1995","journal-title":"Blood"},{"issue":"1","key":"10.5144\/1658-3876.2011.132_bb0155","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1136\/ard.2008.095463","article-title":"Rituximab in diffuse cutaneous systemic sclerosis: an open-label clinical and histopathological study","volume":"69","author":"Smith","year":"2008","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"10.5144\/1658-3876.2011.132_bb0160","doi-asserted-by":"crossref","first-page":"R54","DOI":"10.1186\/ar2965","article-title":"B cell depletion in diffuse progressive systemic sclerosis: safety, skin score modification and IL-6 modulation in an up to thirty-six months follow-up open-label trial","volume":"12","author":"Bosello","year":"2010","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"10.5144\/1658-3876.2011.132_bb0165","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/rheumatology\/kep093","article-title":"Experience with rituximab in scleroderma: results from a 1-year, proof-of-principle study","volume":"49","author":"Daoussis","year":"2009","journal-title":"Rheumatology (Oxford)"},{"key":"10.5144\/1658-3876.2011.132_bb0170","doi-asserted-by":"crossref","DOI":"10.1177\/1753465811407786","article-title":"Cyclophosphamide-refractory scleroderma-associated interstitial lung disease: remarkable clinical and radiological response to a single course of rituximab combined with high-dose corticoste-roids","author":"Haroon","year":"2011","journal-title":"Ther Adv Respir Dis"},{"issue":"4","key":"10.5144\/1658-3876.2011.132_bb0175","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/ajh.20492","article-title":"Changes in the natural history of progressive multifocal leukoencepha-lopathy in HIV-negative lymphoproliferative disorders: impact of novel therapies","volume":"80","author":"Garcia-Suarez","year":"2005","journal-title":"Am J Hematol"},{"issue":"1\u22122","key":"10.5144\/1658-3876.2011.132_bb0180","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jaut.2007.11.013","article-title":"The emergence of progressive multifocal leukoencephalopathy (PML) in rheumatic diseases","volume":"30","author":"Boren","year":"2008","journal-title":"J Autoimmun"}],"container-title":["Hematology\/Oncology and Stem Cell Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1658387611500263?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1658387611500263?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ovid.com\/02275670-201104030-00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:49:47Z","timestamp":1787838587000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/02275670-201104030-00009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.5144\/1658-3876.2011.132","relation":{},"ISSN":["1658-3876"],"issn-type":[{"value":"1658-3876","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}