{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:34:57Z","timestamp":1787841297972,"version":"build-2784847793"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T00:00:00Z","timestamp":1404950400000},"content-version":"vor","delay-in-days":739,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>The development of hematologic malignancy in the presence of chronic lymphocytic leukemia (CLL) is rare. We present a case of acute myeloid leukemia (AML) with del(7q) occurring in a patient with a 4-year history of untreated CLL. Application of flow cytometry and immunohistochemistry allowed for characterization of two distinct coexisting malignant cell populations. After undergoing induction and consolidation chemotherapy, the patient achieved complete remission of AML with the persistence of CLL. Allogeneic transplantation was pursued given his unfavorable cytogenetics. Subsequent matched unrelated donor allogeneic stem cell transplantation resulted in full engraftment and complete remission, with no evidence of AML or CLL. Due to a scarcity of reported cases, insight into treatment and prognosis in cases of concurrent AML and CLL is limited. However, prognosis seems dependent on the chemosen-sitivity of AML. CLL did not have a detrimental effect on treatment or transplant outcome in our case. This is the first reported case of concomitant de novo AML and CLL to undergo allogeneic transplantation. The patient remained in complete hematologic and cytogenetic remission of both malignancies over a year after transplantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5144\/1658-3876.2012.165","type":"journal-article","created":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T11:44:24Z","timestamp":1405511064000},"page":"165-168","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Allogeneic stem cell transplantation for acute myeloid leukemia with del(7q) following untreated chronic lymphocytic leukemia"],"prefix":"10.4103","volume":"5","author":[{"given":"Zachariah","family":"DeFilipp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donny","family":"V. Huynh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salman","family":"fazal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Entezam","family":"Sahovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"5","key":"10.5144\/1658-3876.2012.165_bb0005","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1080\/10428190500404761","article-title":"Concomitant chronic lymphocytic leukemia and acute myeloid leukemia: Evidence of simultaneous expansion of two independent clones","volume":"47","author":"Gottardi","year":"2006","journal-title":"Leuk Lymphoma"},{"key":"10.5144\/1658-3876.2012.165_bb0010","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/10245330410001701503","article-title":"Therapy-related leukemia and MDS: evolving concepts of pathogenesis and treatment","volume":"9","author":"Rund","year":"2004","journal-title":"Hematology"},{"issue":"18","key":"10.5144\/1658-3876.2012.165_bb0015","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1200\/JCO.2002.08.128","article-title":"Therapy-Related Myeloid Leukemia Are Observed in Patients with Chronic Lymphocytic Leukemia After Treatment with Fludarabine and Chlorambucil: Results of an Intergroup Study, Cancer and Leukemia Group B 9011","volume":"20","author":"Morrison","year":"2002","journal-title":"Clin Onc"},{"issue":"12","key":"10.5144\/1658-3876.2012.165_bb0020","first-page":"2047","article-title":"Therapy-Related Leukemia and Myelodysplastic Syndrome in Chronic Lymphocytic Leukemia","volume":"8","author":"Robertson","year":"1994","journal-title":"Leukemia"},{"issue":"3","key":"10.5144\/1658-3876.2012.165_bb0025","first-page":"421","article-title":"Association of B-Chronic Lymphocytic Leukemia and Acute Myeloid Leukemia","volume":"26","author":"Carulli","year":"2007","journal-title":"Exp Clin Cancer Res"},{"key":"10.5144\/1658-3876.2012.165_bb0030","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1080\/10428190600880977","article-title":"Incidence of second neoplasia in patients with B-cell chronic lymphocytic leukemia treated with chlorambucil maintenance chemotherapy","volume":"47","author":"Callea","year":"2006","journal-title":"Leuk Lymphoma"},{"issue":"5","key":"10.5144\/1658-3876.2012.165_bb0035","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1600-0609.1997.tb01698.x","article-title":"Concomitant diagnosis of acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL). Importance of flow cytometry in the diagnosis of CLL without lymphocytosis accompanying AML","volume":"59","author":"G\u00f3mez-Arbon\u00e9s","year":"1997","journal-title":"Eur J Haematol"},{"issue":"4","key":"10.5144\/1658-3876.2012.165_bb0040","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/00000372-200108000-00011","article-title":"Concurrent chronic lymphocytic leukemia cutis and acute myelogenous leukemia cutis in a patient with untreated CLL","volume":"23","author":"Miller","year":"2001","journal-title":"Am J Dermatopathol"},{"key":"10.5144\/1658-3876.2012.165_bb0045","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/0165-4608(95)00262-6","article-title":"Cytogenetic Findings in a Patient Presenting Simultaneously with Chronic Lymphocytic Leukemia and Acute Myeloid Leukemia","volume":"87","author":"Lima","year":"1996","journal-title":"Cancer Genet Cytogenet"},{"issue":"35","key":"10.5144\/1658-3876.2012.165_bb0050","doi-asserted-by":"crossref","first-page":"e726","DOI":"10.1200\/JCO.2010.30.2091","article-title":"Synchronous Diagnosis of Chronic Lymphocytic Leukemia and Acute Myeloid Leukemia","volume":"28","author":"Katz","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.5144\/1658-3876.2012.165_bb0055","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1182\/blood.V96.13.4075","article-title":"Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group\/Eastern Cooperative Oncology Group study","volume":"96","author":"Slovak","year":"2000","journal-title":"Blood"},{"issue":"11","key":"10.5144\/1658-3876.2012.165_bb0060","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1182\/blood-2010-06-291500","article-title":"Transplantation in AML CR1","volume":"116","author":"Savani","year":"2010","journal-title":"Blood"},{"issue":"11","key":"10.5144\/1658-3876.2012.165_bb0065","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1182\/blood-2010-04-278317","article-title":"Comparable survival after HLA-well-matched unrelated or matched sibling donor transplanatation for acute myeloid leukemia in first remission with unfavorable cytogenetics at diagnosis","volume":"116","author":"Gupta","year":"2010","journal-title":"Blood"},{"issue":"7","key":"10.5144\/1658-3876.2012.165_bb0070","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1038\/leu.2010.102","article-title":"Comparison of matched unrelated and matched related donor myeloablative hematopoietic cell transplantation for adults with acute myeloid leukemia in first remission","volume":"24","author":"Walter","year":"2010","journal-title":"Leukemia"},{"key":"10.5144\/1658-3876.2012.165_bb0075","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/sj.leu.2404441","article-title":"Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: the EBMT transplant consensus","volume":"21","author":"Dreger","year":"2007","journal-title":"Leukemia"},{"key":"10.5144\/1658-3876.2012.165_bb0080","first-page":"856","article-title":"Concomitant chronic lymphocytic leukemia (CLL) and acute myeloid leukemia. Complete remission of CLL achieved with high-dose cytosine arabinoside","volume":"6","author":"Caballero","year":"1992","journal-title":"Leukemia"},{"key":"10.5144\/1658-3876.2012.165_bb0085","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/cyto.990180107","article-title":"Two color flow cytometric analysis of concomitant acute myeloid leukemia and chronic lymphocytic leukemia","volume":"18","author":"Tamul","year":"1994","journal-title":"Cytometry"},{"key":"10.5144\/1658-3876.2012.165_bb0090","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/(SICI)1096-8652(199712)56:4<281::AID-AJH15>3.0.CO;2-C","article-title":"Concomitant Chronic Lymphocytic Leukemia and Acute Myeloid Leukemia With an Uncommon Immunophenotype","volume":"56","author":"Mateu","year":"1997","journal-title":"Am J Hematol."},{"key":"10.5144\/1658-3876.2012.165_bb0095","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/ajcp\/111.3.373","article-title":"Untreated Chronic Lymphocytic Leukemia Concurrent With or Followed by Acute Myelogenous Leukemia or Myelodysplastic Syndrome: A Report of Five Cases and Review of the Literature","volume":"111","author":"Lai","year":"1999","journal-title":"Am J Clin Pathol."},{"issue":"8","key":"10.5144\/1658-3876.2012.165_bb0100","first-page":"766","article-title":"Concomitant chronic lymphocytic leukemia and acute myeloid leukemia diagnosedby two color flow cytometric analysis","volume":"84","author":"Yenerel","year":"1999","journal-title":"Haematologica"},{"key":"10.5144\/1658-3876.2012.165_bb0105","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/(SICI)1097-0320(20000415)42:2<114::AID-CYTO5>3.0.CO;2-L","article-title":"Diagnosis of unexpected acute myeloid leukemia and chronic lymphocytic leukemia: A case report demonstrating the perils of restricted panels in flow cytometric immunophenotyping","volume":"42","author":"Xie","year":"2000","journal-title":"Cytometry"},{"key":"10.5144\/1658-3876.2012.165_bb0110","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/BF02982026","article-title":"Acute Myelogenous Leukemia Concurrent with Untreated Chronic Lymphocytic Leukemia","volume":"71","author":"Muta","year":"2002","journal-title":"Int J Hematol."},{"key":"10.5144\/1658-3876.2012.165_bb0115","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/ajh.20716","article-title":"Concurrent Acute Myeloid Leukemia With inv(16)(p13.1q22) and Chronic Lymphocytic Leukemia: Molecular Evidence of Two Separate Diseases","volume":"81","author":"Lu","year":"2006","journal-title":"Am J Hematol."},{"key":"10.5144\/1658-3876.2012.165_bb0120","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1053\/j.seminoncol.2008.04.012","article-title":"Therapy-related myeloid leukemia","volume":"35","author":"Godley","year":"2008","journal-title":"Semin Oncol."}],"container-title":["Hematology\/Oncology and Stem Cell Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1658387612500361?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1658387612500361?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ovid.com\/02275670-201205030-00011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:49:05Z","timestamp":1787838545000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/02275670-201205030-00011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.5144\/1658-3876.2012.165","relation":{},"ISSN":["1658-3876"],"issn-type":[{"value":"1658-3876","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}