{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T02:55:48Z","timestamp":1794365748927,"version":"4.9.0"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"2","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Rheumatology"],"abstract":"<jats:p>Background\/Aims: Osteoarthritis features cartilage degeneration, synovial fibrosis, and bone remodeling. Long-term Western therapies may worsen cartilage damage. We investigated PRDX3\u2019s role in ferroptosis and oxidative stress in osteoarthritis cartilage injury.\nMaterials and Methods: In osteoarthritis models, PRDX3 expression was downregulated. Single-cell analysis showed PRDX3 in patient bone cells.\nResults: Sh-PRDX3 promoted cartilage injury via oxidative stress induction. PRDX3 suppressed ROS accumulation and mitochondria-dependent ferroptosis in vitro and mouse models. PRDX3 induced SIRT3 to reduce SIRT3 ubiquitination. METTL3-mediated m6A modification decreased PRDX3 mRNA stability via YTHDF1.\nConclusion: METTL3-mediated m6A decreases PRDX3 mRNA stability to relieve ferroptosis and oxidative stress in osteoarthritis models. Targeting METTL3 may be therapeutic.<\/jats:p>","DOI":"10.5152\/archrheumatol.2025.11031","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T14:04:31Z","timestamp":1755525871000},"page":"197-210","source":"Crossref","is-referenced-by-count":6,"title":["Methylation of PRDX3 Expression Alleviate Ferroptosis and Oxidative Stress in Patients with Osteoarthritis Cartilage Injury"],"prefix":"10.5152","volume":"40","author":[{"family":"Xia Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Yixue Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Mengsong Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Qishuang Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2025,6,30]]},"container-title":["Archives of Rheumatology"],"original-title":[],"link":[{"URL":"https:\/\/archivesofrheumatology.org\/index.php\/pub\/article\/download\/1487\/2666","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/archivesofrheumatology.org\/index.php\/pub\/article\/download\/1487\/2667","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/archivesofrheumatology.org\/index.php\/pub\/article\/download\/1487\/2666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T08:42:44Z","timestamp":1761208964000},"score":1,"resource":{"primary":{"URL":"https:\/\/archivesofrheumatology.org\/index.php\/pub\/article\/view\/1487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,30]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,6,30]]}},"URL":"https:\/\/doi.org\/10.5152\/archrheumatol.2025.11031","relation":{},"ISSN":["2618-6500"],"issn-type":[{"value":"2618-6500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,30]]}}}