{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T02:55:00Z","timestamp":1785207300264,"version":"3.55.0"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"2","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Rheumatology"],"abstract":"<jats:p>Background\/Aims: Radiographic axial spondyloarthritis (r-axSpA) is a chronic inflammatory arthritis associated with increased cardiovascular (CV) risk due to persistent inflammation. Sestrin-1, an antioxidant and anti-inflammatory protein, has been implicated in CV protection. This study investigated relationships between Sestrin-1 levels, CV markers, and echocardiographic findings in r-axSpA patients.\nMaterials and Methods: Controlled study of 48 r-axSpA patients (modified New York criteria) and 48 age- and sex-matched healthy controls. Collected demographic, biochemical, and echocardiographic data. Measured Sestrin-1 by ELISA; assessed carotid intima-media thickness via ultrasound. Statistical analyses evaluated group differences and correlations between Sestrin-1 and inflammatory\/CV parameters.\nResults: r-axSpA patients had significantly lower Sestrin-1 levels than controls (P = .003). Sestrin-1 negatively correlated with CRP (r = \u20130.42) and ESR (r = \u20130.38). Echocardiography showed increased CIMT (P &lt; .001), reduced RVSM, and lower TAPSE in r-axSpA patients. No correlation between Sestrin-1 and ASDAS-CRP.\nConclusion: r-axSpA patients exhibit reduced Sestrin-1 and subclinical CV changes, suggesting Sestrin-1 may contribute to CV risk in r-axSpA. Further research is needed on Sestrin-1 as a biomarker for CV complications.<\/jats:p>","DOI":"10.5152\/archrheumatol.2025.11138","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T14:04:31Z","timestamp":1755525871000},"page":"230-234","source":"Crossref","is-referenced-by-count":2,"title":["Does Sestrin-1 Mitigate Cardiovascular Risks in Radiographic Axial Spondyloarthritis?"],"prefix":"10.5152","volume":"40","author":[{"family":"Selman Parlak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Ahmet Taha Sahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Ahmet L\u00fctf\u00fc Sertdemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Adem K\u00fc\u00e7\u00fck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Abdullah \u0130\u00e7li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2025,6,30]]},"container-title":["Archives of Rheumatology"],"original-title":[],"link":[{"URL":"https:\/\/archivesofrheumatology.org\/index.php\/pub\/article\/download\/1484\/2660","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/archivesofrheumatology.org\/index.php\/pub\/article\/download\/1484\/2661","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/archivesofrheumatology.org\/index.php\/pub\/article\/download\/1484\/2660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T08:54:57Z","timestamp":1761209697000},"score":1,"resource":{"primary":{"URL":"https:\/\/archivesofrheumatology.org\/index.php\/pub\/article\/view\/1484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,30]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,6,30]]}},"URL":"https:\/\/doi.org\/10.5152\/archrheumatol.2025.11138","relation":{},"ISSN":["2618-6500"],"issn-type":[{"value":"2618-6500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,30]]}}}