{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T20:13:23Z","timestamp":1779135203200,"version":"3.51.4"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Rheumatology"],"abstract":"<jats:p>Background\/Aims: This study aimed to assess the potential of syndecan-1 levels as a biomarker for diagnosing cardiovascular diseases and atherosclerosis in patients with Beh\u00e7et\u2019s disease.\r\nMaterials and Methods: After estimating the required sample size, 56 patients with Beh\u00e7et\u2019s disease and 56 age- and sex-matched controls were enrolled in the study. Carotid intima-media thickness (cIMT) was measured by a single radiologist using an appropriate technique. Syndecan-1 levels were determined with an Syndecan-1 human ELISA kit (CLOUD CLONE, USCN). The test system showed a correlation coefficient of 0.99 between expected and actual values, with a detection limit of around 0.01 ng\/mL. The intra-assay coefficient of variation (CV) was under 10%, and the inter-assay CV was under 12%.\r\nResults: The data obtained from the study showed that syndecan-1 levels (P &lt; .002) and cIMT measurements (P &lt; .015) were significantly higher in patients with Beh\u00e7et\u2019s disease compared to the healthy control group. Additionally, correlation analysis revealed a significant negative relationship between syndecan-1 levels and cIMT. In a stepwise multiple regression analysis, a strong independent relationship was found between cIMT and age (beta [\u03b2]\u2009=\u20090.474, P &lt; .001), syndecan-1 (\u03b2\u2009=\u20090.302, P\u2009=\u2009.007), and low-density lipoprotein (\u03b2\u2009=\u20090.219, P\u2009=\u2009.050).\r\nConclusion: Syndecan-1 levels were higher in patients with Beh\u00e7et\u2019s disease compared to controls, and increased syndecan-1 may slow the progression of subclinical atherosclerosis. This study is a preliminary investigation. Further detailed studies are needed.Cite this article as: Kad\u0131yoran C, Diydem Y\u0131lmaz P, Hakan G\u00f6ktepe M, et\u00a0al. Syndecan-1 as a biomarker for cardiovascular risk in patients with Beh\u00e7et\u2019s disease. Arch Rheumatol. 2025;40(4):435-442.<\/jats:p>","DOI":"10.5152\/archrheumatol.2025.11178","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T08:18:19Z","timestamp":1764577099000},"page":"435-442","source":"Crossref","is-referenced-by-count":2,"title":["Syndecan-1 as a Biomarker for Cardiovascular Risk in Patients with Beh\u00e7et\u2019s Disease"],"prefix":"10.5152","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7173-3530","authenticated-orcid":false,"given":"Cengiz","family":"Kad\u0131yoran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8519-5382","authenticated-orcid":false,"given":"P\u0131nar Diydem","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1711-5157","authenticated-orcid":false,"given":"Mevl\u00fct Hakan","family":"G\u00f6ktepe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2771-6191","authenticated-orcid":false,"given":"Adem","family":"K\u00fc\u00e7\u00fck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8044-7616","authenticated-orcid":false,"given":"Mustafa","family":"O\u011ful","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7807-135X","authenticated-orcid":false,"given":"Erkan","family":"C\u00fcre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9670-0789","authenticated-orcid":false,"given":"Faik","family":"\u00d6zdeng\u00fcl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2025,12,1]]},"container-title":["Archives of Rheumatology"],"original-title":[],"link":[{"URL":"https:\/\/archivesofrheumatology.org\/index.php\/pub\/article\/download\/1516\/2715","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/archivesofrheumatology.org\/index.php\/pub\/article\/download\/1516\/2715","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T08:18:20Z","timestamp":1764577100000},"score":1,"resource":{"primary":{"URL":"https:\/\/archivesofrheumatology.org\/index.php\/pub\/article\/view\/1516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,1]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,12,1]]}},"URL":"https:\/\/doi.org\/10.5152\/archrheumatol.2025.11178","relation":{},"ISSN":["2618-6500"],"issn-type":[{"value":"2618-6500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,1]]}}}