{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T09:08:42Z","timestamp":1773652122152,"version":"3.50.1"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Rheumatology"],"abstract":"<jats:p>Background\/Aims: The hemoglobin, albumin, lymphocyte, and platelet (HALP) score is a novel biomarker reflecting systemic inflammationand nutritional status. While it has been studied in oncology and someinflammatory diseases, its clinical role in rheumatoid arthritis (RA) remainsunclear. This study aimed to investigate the relationship between HALP,disease activity, and inflammatory burden in RA.Materials and Methods: This retrospective cross-sectional study included106 patients with RA diagnosed according to the 2010 ACR\/EULAR criteria and 110 age-, sex-, and BMI-matched healthy controls. Clinical andlaboratory data were recorded, and HALP scores were calculated. Diseaseactivity was assessed using the disease activity score-28-C-reactive protein(DAS28-CRP). Group comparisons, Spearman correlation analysis, receiveroperating characteristic (ROC) curve analysis, and multivariable logisticregression were performed.Results: The HALP scores were significantly lower in patients with RA compared with healthy controls (P &lt; .0001). Among patients with RA, thosewith active disease exhibited significantly lower HALP scores than thosein remission (P &lt; .05), with a decreasing trend across DAS28-CRP diseaseactivity categories. The HALP scores showed negative correlations withCRP (r\u2009=\u2009\u22120.329), Visual Analog Scale (VAS)-pain (r = \u22120.399), and DAS28-CRP(r\u2009=\u2009\u22120.348) (all P \u2264 .001). The ROC analysis demonstrated moderate discriminative ability for distinguishing active disease from remission (AUC\u2009=\u20090.708,95% CI: 0.63-0.81). In multivariable logistic regression analysis, lower HALPscores and older age were independently associated with active RA.Conclusion: The study demonstrates that lower HALP scores are associated with higher disease activity in rheumatoid arthritis. As a simple androutinely available laboratory-based index, the HALP score may serve as asupportive marker of inflammatory burden. Prospective multicenter studies are required to validate these findings and to clarify the longitudinalutility of the HALP score.Cite this article as: \u00c7elik G,\u00c7ilingiro\u011flu \u00c7, U\u011fur S, K\u0131z\u0131l \u015eD.Clinical relevance of the HALP scorein rheumatoid arthritis: Associationwith disease activity andinflammatory burden.ArchRheumatol. Published onlineMarch 13, 2026. doi: 10.5152\/ArchRheumatol.2026.25181.<\/jats:p>","DOI":"10.5152\/archrheumatol.2026.25181","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T08:34:57Z","timestamp":1773650097000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical Relevance of the HALP Score in Rheumatoid Arthritis: Association with Disease Activity and Inflammatory Burden"],"prefix":"10.5152","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1170-4110","authenticated-orcid":false,"given":"G\u00fcl\u015fah","family":"\u00c7elik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6269-486X","authenticated-orcid":false,"given":"\u00c7i\u011fdem","family":"\u00c7ilingiro\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5617-629X","authenticated-orcid":false,"given":"Sevcan","family":"U\u011fur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6490-6408","authenticated-orcid":false,"given":"\u015eevval","family":"Dirican K\u0131z\u0131l","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2026,3,13]]},"container-title":["Archives of Rheumatology"],"original-title":[],"link":[{"URL":"https:\/\/archivesofrheumatology.org\/index.php\/pub\/article\/download\/1548\/2753","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/archivesofrheumatology.org\/index.php\/pub\/article\/download\/1548\/2753","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T08:34:58Z","timestamp":1773650098000},"score":1,"resource":{"primary":{"URL":"https:\/\/archivesofrheumatology.org\/index.php\/pub\/article\/view\/1548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,13]]},"references-count":0,"URL":"https:\/\/doi.org\/10.5152\/archrheumatol.2026.25181","relation":{},"ISSN":["2618-6500"],"issn-type":[{"value":"2618-6500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,13]]}}}