{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:38:16Z","timestamp":1767055096860,"version":"3.48.0"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["EAJM"],"abstract":"<jats:p>Abstract\n\tAma\u00e7: \u00c7al\u0131\u015fmam\u0131zda kronik periton diyalizi (KPD) hastalar\u0131nda klotho gen polimorfizmi (KGP) ve kemik mineral yo\u011funlu\u011fu (KMY) ile baz\u0131 major kemik metabolizma belirte\u00e7leri aras\u0131ndaki ili\u015fkinin ara\u015ft\u0131r\u0131lmas\u0131 ama\u00e7lanm\u0131\u015ft\u0131r.\n\n\t \n\n\tGere\u00e7 ve Y\u00f6ntem: \u00c7al\u0131\u015fmaya dahil edilen 51 KPD hastas\u0131 ve 40 sa\u011fl\u0131kl\u0131 kontrol grubunda intakt parathormon (iPTH), fibroblast b\u00fcy\u00fcme fakt\u00f6r (FGF-23), osteoprotogerin (OPG), osteokalsin (OK), prokollajen tip-1 N terminal propeptid (PINP), beta- crosslaps (beta KTx), tartarate resistan asid fosfataz (TRAF5b), kemik alkalen fosfataz (KAF), 1,25(OH)D3, 25(OH)D3 ve a-klotho gen mutasyonlar\u0131 \u00f6l\u00e7\u00fcld\u00fc.\n\n\t \n\n\tBulgular: 51 KPD hastas\u0131nda 1,25(OH)D3 ve 25(OH)D3 eksikli\u011fi oran\u0131 s\u0131ras\u0131yla %96 ve %94 olarak tespit edildi. iPTH (249 pg\/mL ve 39 pg\/mL) ve FGF-23 (1089 RU\/mL ve 153 RU\/mL), OPG, OK, PINP, beta CTx, TRAP5b seviyeleri hastalarda istatistiksel olarak anlaml\u0131 derecede daha y\u00fcksek bulundu. Hastalarda iPTH seviyeleri ve t\u00fcm v\u00fccut KMY aras\u0131nda negatif korelasyon tespit edildi. KGP oran\u0131 gruplar aras\u0131nda benzer bulundu.\n\n\t \n\n\tSonu\u00e7: Kronik periton diyalizi hastalar\u0131nda D vitamin eksikli\u011fine ek olarak, OPG, OK, PINP, beta CTx, TRAP5b d\u00fczeyleri y\u00fcksek saptand\u0131. iPTH seviyeleri ile KAF ve PINP aras\u0131ndaki pozitif korelasyon bu belirte\u00e7lerin kronik b\u00f6brek hastalar\u0131ndaki (KBH) kemik mineral hastal\u0131klar\u0131n\u0131n (KMH) tedavisinde tan\u0131sal de\u011ferinin oldu\u011funu g\u00f6stermi\u015ftir.   Di\u011fer taraftan y\u00fcksek serum TRAP5b konsantrasyonunun kalsitriol tedavisi ve hiperparatiroidinin \u015fiddetinden etkilenmedi\u011fi de g\u00f6sterilmi\u015ftir. iPTH ve FGF-23 d\u00fczeyleri ile t\u00fcm v\u00fccut KMY aras\u0131nda anlaml\u0131 negatif korelasyon tespit edilmi\u015ftir. \u00c7al\u0131\u015fmam\u0131zda klotho gen polimorfizmi ile KBH-KMH\u2019n\u0131n hi\u00e7bir belirteci aras\u0131nda anlaml\u0131 korelasyon g\u00f6sterilememi\u015ftir.<\/jats:p>","DOI":"10.5152\/eurasianjmed.2015.93","type":"journal-article","created":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T13:18:28Z","timestamp":1433942308000},"page":"115-125","source":"Crossref","is-referenced-by-count":3,"title":["FGF-23, \u03b1-Klotho Gene Polymorphism and Their Relationship with the Markers of Bone Metabolism in Chronic Peritoneal Dialysis Patients"],"prefix":"10.5152","volume":"47","author":[{"given":"Vural Taner","family":"Yilmaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebahat","family":"Ozdem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levent","family":"Donmez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramazan","family":"Cetinkaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gultekin","family":"Suleymanlar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. Fevzi","family":"Ersoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2019,9,3]]},"container-title":["The Eurasian Journal of Medicine"],"original-title":[],"link":[{"URL":"https:\/\/eajm.org\/index.php\/pub\/article\/download\/2609\/2606","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:33:00Z","timestamp":1767054780000},"score":1,"resource":{"primary":{"URL":"https:\/\/eajm.org\/index.php\/pub\/article\/view\/2609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,3]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,1,1]]}},"URL":"https:\/\/doi.org\/10.5152\/eurasianjmed.2015.93","relation":{},"ISSN":["1308-8742"],"issn-type":[{"type":"electronic","value":"1308-8742"}],"subject":[],"published":{"date-parts":[[2019,9,3]]}}}