{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:08:40Z","timestamp":1788390520224,"version":"build-2803163510"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["EAJM"],"abstract":"<jats:p>Objective: T-helper cells (Th)-1&amp; -2 cytokines homeostasis control or predict clinical outcome of infected persons, especially those with HIV \/AIDS. This case-control study evaluated the leucocytes differentials, TNF-alpha, interleukin (IL)-2 and -10 levels among HIV infected persons with serological evidence of leishmaniasis attending University of Abuja Teaching Hospital, Nigeria\n\nMaterials and Methods: Blood samples from 28 HIV infected persons who had Leishmania donovani rK39 and Immunoglobulin-G (IgG) positive (group 1), 30 age- &amp; -sex matched HIV infected persons without Leishmania antibodies (group 2) and 30 apparently healthy persons without HIV and Leishmania antibodies (group 3). Full blood counts, TNF alpha, IL-2 and -10 levels were analyzed using automated hematology analyzer and ELISA, respectively. Structured questionnaires were used to collate biodata and clinical presentations of participants.\n\nResults: Ten (35.7%) participants in group 1 were on ART, 15 (50%) in group 2 were on ART, while group 3 were ART na\u00efve. There were significantly higher values in basophil (4.4\u00b12.5%) and eosinophil counts (12.9\u00b13.8%) in HIV\/leishmania coinfected persons (p&lt;0.005). However, other white cells subpopulation was significantly lower in HIV\/leishmania co-infected participants (p&lt;0.05). There was significantly reduced CD4+ T cell counts ([119\u00b126 versus 348\u00b163 versus 605\u00b1116 cells\/mm3]), TNF-alpha ([36.82\u00b18.21 versus 64.67\u00b112.54 versus 254.98\u00b165.59 pg\/mL]) and IL-2 levels ([142.14\u00b120.91 versus 507.6\u00b184.42 versus 486.62\u00b1167.87 pg\/mL]) among HIV\/Leishmania co-infected participants compared to group 2 and group 3 participants, respectively. However, higher IL-10 level (80.35\u00b114.57 pg\/mL) was found in HIV\/Leishmania co-infected participants as opposed to the HIV monoinfected (62.2\u00b110.43 pg\/mL) and apparently healthy persons (23.97\u00b14.88 pg\/mL) (p&lt;0.001).\n\nConclusion: Eosinophil, basophil counts and serum IL-10 level were high in HIV\/Leishmania coinfected persons, demonstrating parasite-induced hypersensitivity and immunosuppression.\n\nCite this article as: Abdullahi IN, Emeribe AU, Adekola HA, et al. Leucocytes and Th-associated Cytokine Profile of HIV-Leishmaniasis Co-Infected Persons Attending Abuja Teaching Hospital, Nigeria. Eurasian J Med 2020; 52(3): 271-6.<\/jats:p>","DOI":"10.5152\/eurasianjmed.2020.20008","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T05:42:35Z","timestamp":1603863755000},"page":"271-276","source":"Crossref","is-referenced-by-count":5,"title":["Leucocytes and Th-associated Cytokine Profile of HIV-Leishmaniasis Co-Infected Persons Attending Abuja Teaching Hospital, Nigeria"],"prefix":"10.5152","volume":"52","author":[{"given":"Idris Nasir","family":"Abdullahi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony Uchenna","family":"Emeribe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafeez Aderinsayo","family":"Adekola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habiba Yahaya","family":"Muhammad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdurrahman","family":"El-fulaty Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abubakar","family":"Umar Anka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamsuddeen","family":"Haruna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bamidele Soji","family":"Oderinde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halima Ali","family":"Shuwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adamu","family":"Babayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2020,10,28]]},"container-title":["The Eurasian Journal of Medicine"],"original-title":[],"link":[{"URL":"https:\/\/eajm.org\/index.php\/pub\/article\/download\/2927\/2923","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T23:51:31Z","timestamp":1767052291000},"score":1,"resource":{"primary":{"URL":"https:\/\/eajm.org\/index.php\/pub\/article\/view\/2927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,28]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,1,1]]}},"URL":"https:\/\/doi.org\/10.5152\/eurasianjmed.2020.20008","relation":{},"ISSN":["1308-8742"],"issn-type":[{"value":"1308-8742","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,28]]}}}