{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T04:03:31Z","timestamp":1754193811343,"version":"3.41.2"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["EJR"],"abstract":"<jats:p>Abstract\n\tObjective: This study aimed to investigate the relations between calreticulin (CRT) serum level and both disease activity and severity parameters in juvenile idiopathic arthritis (JIA).\n\n\t\u00a0\n\n\tMaterial and Methods: In this study, 60 children with JIA and 50 age-and-sex-matched healthy subjects were enrolled. The assessment of the disease activity was done using juvenile arthritis disease activity score 27 (JADAS-27). The assessment of disease severity was done via gray-scale ultrasonography (US) and power Doppler US (PDUS). Enzyme-linked immunosorbent assay (ELISA) was used to assay the serum level of human CRT.\n\n\t\u00a0\n\n\tResults: The mean serum CRT levels in JIA patients was 8.6\u00b11.2 ng\/mL and showed a highly significant increase (p=0.001) as compared to the mean serum levels in the controls (5.02\u00b10.77 ng\/mL). There were statistically significant positive correlations between the serum CRT levels and disease duration, tender joint count, swollen joint count, visual analog scale, erythrocyte sedimentation rate, JADAS-27, C-reactive protein, rheumatoid factor titer, and ultrasonographic grading for synovitis and neovascularization.\n\n\t\u00a0\n\n\tConclusion: Elevated serum CRT levels in JIA patients and its correlations with JIA disease activity and severity parameters signified that CRT might be used as a novel biomarker for disease activity and severity in JIA.\n\n\t\n<\/jats:p>","DOI":"10.5152\/eurjrheum.2017.160071","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T08:21:41Z","timestamp":1488356501000},"page":"19-23","source":"Crossref","is-referenced-by-count":6,"title":["Serum calreticulin as a novel biomarker of juvenile idiopathic arthritis disease activity"],"prefix":"10.5152","volume":"4","author":[{"given":"Nashwa Ismail","family":"Hashaad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha Mohamed","family":"Fawzy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abeer Ahmed","family":"Abo Elazem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Ibrahim","family":"Youssef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2019,9,3]]},"container-title":["European Journal of Rheumatology"],"original-title":[],"link":[{"URL":"https:\/\/www.eurjrheumatol.org\/index.php\/pub\/article\/download\/151\/151","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T07:27:50Z","timestamp":1753774070000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurjrheumatol.org\/index.php\/pub\/article\/view\/151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,3]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,9,3]]}},"URL":"https:\/\/doi.org\/10.5152\/eurjrheum.2017.160071","relation":{},"ISSN":["2148-4279"],"issn-type":[{"type":"electronic","value":"2148-4279"}],"subject":[],"published":{"date-parts":[[2019,9,3]]}}}