{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T19:08:24Z","timestamp":1754161704939,"version":"3.41.2"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["EJR"],"abstract":"<jats:p>Abstract\n\tObjective: Beh\u00e7et\u2019s disease (BD), a chronic multisystem inflammatory disorder, is mainly characterized by relapsing periods of a wide range of clinical symptoms. Several cytokine genes may play important roles in the pathogenesis of BD. Therefore, interleukin-1 receptor antagonist (IL-1Ra) gene 86bp variable number tandem repeat (VNTR) variant was investigated in patients with BD in a Turkish population.\n\n\t\u00a0\n\n\t\n\n\tMethods: One hundred nine patients (60 females, 49 males; the mean age\u00b1standard deviation [SD] was 36.56\u00b19.571 years) with BD and one hundred healthy individuals (54 females, 46 males; the mean age\u00b1SD was 36.64\u00b12.294 years) were examined in the study. For genotyping, polymerase chain reaction-restriction fragment length polymorphism analysis was employed. Data were analyzed using Statistical Package for Social Sciences (SPSS) 22.0 (p0.05). The frequency of the a1\/a1, a1\/a2 genotypes and a1, a2 alleles were the most common both in patients and healthy controls (p=0.37, p=0.26, and p=0.53, respectively). Also, no statistically significant difference was found between the IL-1Ra VNTR variant genotypes and clinical characteristics (p&gt;0.05).\n\n\t\u00a0\n\n\t\n\n\tConclusion: The results of this study do not support an association between the IL-1Ra VNTR variant and the risk of BD in a Turkish population. However, further studies of this variant with larger sample sizes and different ethnicities are required for confirmation.\u00a0\n\n\t\u00a0\n\n\tCite this article as: Dursun G, Nursal AF, Deniz Demir H, Karaku\u015f N, Demir O, Yi\u011fit S. Investigation of the role of interleukin-1 receptor antagonist VNTR variant on the Beh\u00e7et\u2019s disease. Eur J Rheumatol 2018; 5: 27-31.\n<\/jats:p>","DOI":"10.5152\/eurjrheum.2017.16102","type":"journal-article","created":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T03:45:23Z","timestamp":1505792723000},"page":"27-31","source":"Crossref","is-referenced-by-count":2,"title":["Investigation of the role of interleukin-1 receptor antagonist VNTR variant on the Beh\u00e7et\u2019s disease"],"prefix":"10.5152","volume":"5","author":[{"given":"G\u00fcl","family":"Dursun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ay\u015fe Feyda","family":"Nursal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helin Deniz","family":"Demir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nevin","family":"Karaku\u015f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman","family":"Demir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serb\u00fclent","family":"Yi\u011fit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2019,9,3]]},"container-title":["European Journal of Rheumatology"],"original-title":[],"link":[{"URL":"https:\/\/www.eurjrheumatol.org\/index.php\/pub\/article\/download\/226\/226","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T07:26:42Z","timestamp":1753774002000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurjrheumatol.org\/index.php\/pub\/article\/view\/226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,3]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,9,3]]}},"URL":"https:\/\/doi.org\/10.5152\/eurjrheum.2017.16102","relation":{},"ISSN":["2148-4279"],"issn-type":[{"type":"electronic","value":"2148-4279"}],"subject":[],"published":{"date-parts":[[2019,9,3]]}}}