{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:51:13Z","timestamp":1792457473071,"version":"4.5.0"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["EJR"],"abstract":"<jats:p>Systemic sclerosis (SSc) is a connective tissue disorder characterized by immunologic, vascular, and extracellular matrix abnormalities. Variation in the proportion and\/or timing of activation in the deregulated molecular pathways that underlie SSc may explain the observed clinical heterogeneity in terms of disease phenotype and treatment response. In recent years, SSc research has generated massive amounts of \u201comics\u201d level data. In this review, we discuss the body of \u201comics\u201d level work in SSc and how each layer provides unique insight to our understanding of SSc. We posit that effective integration of genomic, transcriptomic, metagenomic, and epigenomic data is an important step toward precision medicine and is vital to the identification of effective therapeutic options for patients with SSc.\n\nCite this article as: Mehta BK, Espinoza ME, Hinchcliff M, Whitfield ML. Molecular \u201comic\u201d signatures in systemic sclerosis. Eur J Rheumatol 2020; 7(Suppl 3): S173-80.\n<\/jats:p>","DOI":"10.5152\/eurjrheum.2020.19192","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T17:16:23Z","timestamp":1603818983000},"page":"S173-S180","source":"Crossref","is-referenced-by-count":13,"title":["Molecular \u201comic\u201d signatures in systemic sclerosis"],"prefix":"10.5152","volume":"7","author":[{"given":"Bhaven K.","family":"Mehta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica E.","family":"Espinoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Hinchcliff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Whitfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2020,10,27]]},"container-title":["European Journal of Rheumatology"],"original-title":[],"link":[{"URL":"https:\/\/www.eurjrheumatol.org\/index.php\/pub\/article\/download\/436\/436","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T07:16:10Z","timestamp":1753773370000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurjrheumatol.org\/index.php\/pub\/article\/view\/436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,27]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,8,5]]}},"URL":"https:\/\/doi.org\/10.5152\/eurjrheum.2020.19192","relation":{},"ISSN":["2148-4279"],"issn-type":[{"value":"2148-4279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,27]]}}}