{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T16:57:00Z","timestamp":1754153820586,"version":"3.41.2"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["imaging-interv"],"abstract":"<jats:p>Background:\u00a0Although most thyroid nodules with indeterminate cytology (Bethesda III\/IV) are benign, they represent a manage- ment dilemma possibly leading to unnecessary surgery. This study aims to evaluate the role of magnetic resonance imaging inthe risk stratification of thyroid nodules with indeterminate cytology.\n\nMethods:\u00a0Patients scheduled for thyroidectomy for thyroid nodules with indeterminate cytology were prospectively enrolled.Diffusion-weighted images and T2-weighted images were obtained. Apparent diffusion coefficient values and T2-weighted sig- nal intensities of thyroid nodules, normal thyroid parenchyma, muscle tissue, and spinal cord were recorded.\n\nResults:\u00a0In the final analysis, 17 nodules (5 malignant and 12 benign) were included. Apparent diffusion coefficient values, nodule- to-spinal cord apparent diffusion coefficient ratio, and nodule-to-muscle T2 signal intensity ratio were significantly lower inmalignant nodules (P\u00a0= .019,\u00a0P\u00a0= .019 and\u00a0P\u00a0= .037, respectively). Using a threshold of 1.570\u00a0\u00d710\u22123\u00a0mm2\/s, nodule apparent diffusioncoefficient value had a sensitivity of 100%, specificity of 75%, positive predictive value of 62.5%, negative predictive value of 100%, and an accuracy of 82.4%. At a threshold of 3.831, nodule-to-muscle T2-weighted signal intensity ratio had a sensitivity of 100%, specificity of 50%, positive predictive value of 45.5%, and negative predictive value of 100%. If falling under both of thesethreshold values was required for the diagnosis of malignancy, then the sensitivity and negative predictive value would remainunchanged at 100%, but there would be an increase in specificity, positive predictive value, and accuracy to 83.3%, 71.4%, and 88.2%, respectively. Furthermore, 83.3% (10\/12) of benign nodules could have been spared from unnecessary surgery.\n\nConclusion:\u00a0Magnetic resonance imaging is a very sensitive tool for discriminating benign from malignant thyroid nodules with indeterminate cytology and it may spare patients from unnecessary surgery.\n\nCite this article as:\u00a0Awiwi MO, Teks\u00f6z S, Akba\u015f S, Gjoni M, K\u0131z\u0131lk\u0131l\u0131\u00e7 O. Should we use magnetic resonance imaging for thyroid nodules with indeterminate cytology? Imaging Interv. 2022;1(3):52-60.\n<\/jats:p>","DOI":"10.5152\/iai.2021.21028","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T01:31:13Z","timestamp":1652146273000},"page":"52-60","source":"Crossref","is-referenced-by-count":0,"title":["Should We Use Magnetic Resonance Imaging for Thyroid Nodules with Indeterminate Cytology?"],"prefix":"10.5152","volume":"1","author":[{"given":"Muhammad O.","family":"Awiwi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serkan","family":"Teks\u00f6z","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serkan","family":"Akba\u015f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Migena","family":"Gjoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman","family":"K\u0131z\u0131lk\u0131l\u0131\u00e7","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2022,5,9]]},"container-title":["IMAGING &amp; INTERVENTION"],"original-title":[],"link":[{"URL":"https:\/\/imaging-interv.org\/index.php\/pub\/article\/download\/13\/13","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T14:28:45Z","timestamp":1753280925000},"score":1,"resource":{"primary":{"URL":"https:\/\/imaging-interv.org\/index.php\/pub\/article\/view\/13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,9]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,12,1]]}},"URL":"https:\/\/doi.org\/10.5152\/iai.2021.21028","relation":{},"ISSN":["2791-805X"],"issn-type":[{"type":"electronic","value":"2791-805X"}],"subject":[],"published":{"date-parts":[[2022,5,9]]}}}