{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:58:57Z","timestamp":1790251137082,"version":"4.1.0"},"reference-count":0,"publisher":"Caleo","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Adv Otol."],"abstract":"<jats:p>Abstract\n\tOBJECTIVE: The purpose of the study is to prevent hearing loss when using intratympanic (IT) gentamicin for intractable Meniere\u2019s disease. \n\n\t\u00a0\n\n\tMATERIALS and METHODS: It is a retrospective case review study. Twenty five patients who had definite Meniere\u2019s disease and had either selective window application or weekly IT gentamicin were included into the study. First group (selective) had dexamethasone on the round window and gentamicin on oval window during exploratory tympanotomy procedure. The second group had IT gentamicin at weekly intervals. The degree of caloric weakness (CW), average hearing level in low pitch (HLP) (250, 500, 1000, 2000 Hz) and high pitch (HHP) (4000, 6000, 8000 Hz) were compared before and after treatment. The need for further treatment was noted.\n\n\t\u00a0\n\n\tRESULTS: In the first group, the average HLP was increased from 51.6\u00b17dB to 52.2\u00b15.6 dB. The average HHP was increased 41.96\u00b120.2 dB to 47.2\u00b118.3 dB after treatment.\u00a0 The CW changed from 37.6\u00b123.9 % to 54.6\u00b130.6 %. In the second group, the average HLP was increased from 56.3\u00b110.5 dB to 61.65\u00b118.3 dB. The average HHP was increased 59.05\u00b117.4 dB to 69.4\u00b121.98 dB after treatment.\u00a0 The CW changed from 45.8\u00b122.3% to 71.53\u00b129.63 %. Both methods had statisticaly significant increase in caloric weakness. But only IT gentamicin led a significant hearing loss in HHP.\n\n\t\u00a0\n\n\tCONCLUSION: The use of dexamethasone and gentamycin via different windows in the middle ear is safe and effective method for Meniere\u2019s disease in the short term. Application of dexamethasone protects not only the hearing cells but vestibular cells also.\n\n\t\n\n\t\u00a0\n\n\t\u00a0\n\n\tCite this article as: Ard\u0131\u00e7 FN, T\u00fcmkaya F, Aykal K, \u00c7abuk B. Selective Window Application of Gentamicin + Dexamethasone In Meniere\u2019s Disease. J Int Adv Otol 2017; 13: 243-6.<\/jats:p>","DOI":"10.5152\/iao.2017.3483","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T03:22:21Z","timestamp":1500348141000},"page":"243-246","source":"Crossref","is-referenced-by-count":6,"title":["Selective Window Application of Gentamicin+ Dexamethasone in Meniere's Disease"],"prefix":"10.65717","volume":"13","author":[{"given":"Faz\u0131l Necdet","family":"Ard\u0131\u00e7","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Funda","family":"T\u00fcmkaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"Aykal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bur\u00e7in","family":"\u00c7abuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"55248","published-online":{"date-parts":[[2019,9,3]]},"container-title":["The Journal of International Advanced Otology"],"original-title":[],"link":[{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/download\/934\/932","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/download\/917\/915","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/download\/917\/915","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T11:37:03Z","timestamp":1769081823000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/view\/917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,3]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,9,3]]}},"URL":"https:\/\/doi.org\/10.5152\/iao.2017.3483","relation":{},"ISSN":["2148-3817"],"issn-type":[{"value":"2148-3817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,3]]}}}