{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:32:17Z","timestamp":1781879537273,"version":"3.54.5"},"reference-count":0,"publisher":"Caleo","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Adv Otol."],"abstract":"<jats:p>OBJECTIVES: (1) To test the effect of local administration of insulin-like growth factor-1 (IGF-1) in patients with sensorineural hearing loss (SNHL).\u00a0(2) To test the effect of local administration of IGF-1 in patients with ototoxicity.\n\nMETHODS: Forty patients with SNHL were included in the study. Their hearing thresholds at different frequencies (0.5, 1, 2, and 4 kHz) along with\u00a0the average hearing threshold were noted. The patients were then randomly allocated to 2 groups and were treated with IGF-1 via one of the\u00a0following routes: (1) intratympanic injection and (2) Gelfoam.\u00a0Patients were followed-up at weekly intervals for 6 weeks but follow-up PTA was done at 3 weeks, 6 weeks, and 6 months only.\n\nRESULTS: Forty patients (25 male, 15 female) participated in the study. Their age ranged from 13 to 63 years, with a mean of 31.3 years. Nineteen\u00a0(47.5%) patients exhibited some degree of recovery after 6 months of follow-up, while 21 (52.5%) did not exhibit any recovery. Fourteen (35%)\u00a0patients showed slight recovery (SR), 1 (4%) patient showed marked recovery, and complete recovery was observed in 4 (10%) patients. Twelve of\u00a0the 20 patients who underwent treatment using Gelfoam showed improvement in hearing (measured as a reduction in hearing threshold), while\u00a0only 7 of the 20 patients who underwent intratympanic injection showed such improvement. Among adverse reactions, the most common was\npain (88%) which typically did not last beyond 3 days. Other adverse reactions observed were dizziness (24%) and headache (20%). One patient\u00a0suffered from acute suppurative otitis media (ASOM) and had a perforation in the tympanic membrane. However, this was treated successfully\u00a0with medications.\n\nCONCLUSION: Intratympanic IGF-1 is a novel drug that has shown early promise in controlling and reversing SNHL.\n\nCite this article as: Dave V, Joshi A, Bradoo R, Prajapati M, Shah K. Effects of insulin-like growth factor (IGF-1) in patients with sensorineural hearing loss. J Int Adv Otol. 2021;17(3):207-214.<\/jats:p>","DOI":"10.5152\/iao.2021.8549","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T09:09:27Z","timestamp":1622797767000},"page":"207-214","source":"Crossref","is-referenced-by-count":8,"title":["Effects of Insulin-Like Growth Factor (IGF-1) in Patients with Sensorineural Hearing Loss"],"prefix":"10.65717","volume":"17","author":[{"given":"Varun Jitendra","family":"Dave","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anagha","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renuka","family":"Bradoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Prajapati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kshitij","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"55248","published-online":{"date-parts":[[2021,5,1]]},"container-title":["The Journal of International Advanced Otology"],"original-title":[],"link":[{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/download\/1488\/1486","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/download\/1506\/1503","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/download\/1506\/1503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T10:43:21Z","timestamp":1769078601000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/view\/1506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,1]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,5,31]]}},"URL":"https:\/\/doi.org\/10.5152\/iao.2021.8549","relation":{},"ISSN":["2148-3817"],"issn-type":[{"value":"2148-3817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,1]]}}}