{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T01:50:44Z","timestamp":1769133044509,"version":"3.49.0"},"reference-count":0,"publisher":"Caleo","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Adv Otol."],"abstract":"<jats:p>BACKGROUND: The aim of this study was to compare the differential Ki-67 and p27 staining properties of acquired cholesteatoma in adult\u00a0patients for prognostic analysis.\n\nMETHODS: Forty-two adult patients with acquired cholesteatoma were enrolled. The cholesteatoma and matched meatal skin tissues of the\u00a0patients were immunostained with Ki-67 and p27 antibodies. Canal wall down mastoidectomy was performed in all patients. The differential\u00a0staining properties\u2013\u2013positive staining in the cholesteatoma and negative staining in the skin tissue (C+S-), negative staining in the cholesteatoma\u00a0and positive staining in the skin tissue(C-S+)\u2013\u2013were compared for bone erosion scores (BES), stage, and recurrence rates.\n\nRESULTS: Isolated findings in the cholesteatoma tissues, without matching with the skin tissues, demonstrated that stage and recurrence rates\u00a0were not related to findings in the cholesteatoma tissues (P \u02c3 .05). However, C+S- for Ki-67 and C-S+ for p27 are risk factors for worse prognosis\u00a0including advanced stage (P &lt; .001 for Ki-67 and P = .008 for p27), BES values (P &lt; .001 for Ki-67 and P = .001 for p27), and recurrence rates (P &lt;\u00a0.001 for Ki-67 and P = .037 for p27).\n\nCONCLUSION: This is the first paper assessing the cholesteatoma prognosis according to the differential Ki-67 and p27 staining properties of\u00a0cholesteatoma and healthy skin tissues. Cellular proliferation rate in the cholesteatoma is important but insufficient by itself for predicting the\u00a0prognosis of cholesteatoma patients. Patients having lower basal levels of cellular proliferation rate and higher cellular activity in the cholesteatoma\u00a0tissue are prone to worse prognosis with increased stage, recurrence rates, and degree of bone erosion.\n\nCite this article as: T\u00fcrkili S, G\u00f6r\u00fcr K, \u0130smi O, Serins\u00f6z Linke E, Vay\u0131so\u011flu Y, \u00d6zcan C. Differential expression of Ki-67 and P27 in cholesteatoma\u00a0compared to skin tissue predicts the prognosis of adult acquired cholesteatoma. J IntAdv Otol. 2021; 17(4): 306-312.<\/jats:p>","DOI":"10.5152\/iao.2021.9453","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T09:18:34Z","timestamp":1626427114000},"page":"306-312","source":"Crossref","is-referenced-by-count":2,"title":["Differential Expression of Ki-67 and P27 in Cholesteatoma Compared to Skin Tissue Predicts the Prognosis of Adult Acquired Cholesteatoma"],"prefix":"10.65717","volume":"17","author":[{"given":"Serkan","family":"T\u00fcrkili","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kemal","family":"G\u00f6r\u00fcr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onur","family":"\u0130smi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebru","family":"Serins\u00f6z Linke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuf","family":"Vay\u0131so\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cengiz","family":"\u00d6zcan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"55248","published-online":{"date-parts":[[2021,7,1]]},"container-title":["The Journal of International Advanced Otology"],"original-title":[],"link":[{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/download\/1507\/1505","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/download\/1534\/1531","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/download\/1534\/1531","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T10:42:37Z","timestamp":1769078557000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/view\/1534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,1]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,7,16]]}},"URL":"https:\/\/doi.org\/10.5152\/iao.2021.9453","relation":{},"ISSN":["2148-3817"],"issn-type":[{"value":"2148-3817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,1]]}}}