{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T02:51:22Z","timestamp":1769136682931,"version":"3.49.0"},"reference-count":0,"publisher":"Caleo","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Adv Otol."],"abstract":"<jats:p>BACKGROUND:\u00a0Platelet-rich plasma is a frequently used plasma-derived material; however, a possible neoplastic or proliferative effect is one of the limiting issues in its use. The aim of our experimental study was to investigate the long-term histological effects of platelet-rich plasma on the middle ear mucosa.\n\nMETHODS:\u00a0The rats were divided into 2 groups randomly (groups 1 and 2). Group 1 represented the control group and 8 rats were included in this group. To the left ear, 0.3 mL of normal saline solution was administered intra-tympanically. No injections were done to the right ears. Group 2 represented the platelet-rich plasma group and 11 rats were included. To the left ears, 0.3 mL of platelet-rich plasma and to the right ears 0.3 mL of normal saline solution was administered intra-tympanically. The intra-tympanic platelet-rich plasma injections were done twice with an interval of 1 week. All animals were sacrificed in the third month. The degree of mucosal thickness, the presence of metaplasia, atypical cells, myofibroblastic infiltration, angiogenesis, and acute or chronic inflammation were evaluated histopathologically.\n\nRESULTS:\u00a0Histopathological findings in the right and left ears in each group were compared in itself. The degree of inflammation and mucosal thickness were significantly higher in the perforated and saline administered side, in group 1 (P\u00a0&lt;\u00a0.001). In group 2, the degree of angiogenesis was significantly higher in the platelet-rich plasma administered side (P\u00a0&lt;\u00a0.001). The degree of mucosal thickness was significantly higher in the saline administered side (P\u00a0&lt;\u00a0.001).\n\nCONCLUSION:\u00a0Considering the anti-inflammatory and regenerative features and its safety, intra-tympanic-PRP may, in the future, be an alterna- tive to current intra-tympanic treatment modalities.\n\nCite this article as: Arslan N, Kargin Kaytez S, Ocal R, Yumusak N, \u015eenes M, Ibas M. Possible neoplastic or proliferative effects of intra-tympanic platelet-rich plasma on the middle ear mucosa: A myth or a fact to consider?.\u00a0J Int Adv Otol.\u00a02022;18(3):252-256.<\/jats:p>","DOI":"10.5152\/iao.2022.20116","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T01:44:15Z","timestamp":1653011055000},"page":"252-256","source":"Crossref","is-referenced-by-count":1,"title":["Possible Neoplastic or Proliferative Effects of Intra-Tympanic Platelet-Rich Plasma on the MiddleEarMucosa: A Myth or a Fact to Consider?"],"prefix":"10.65717","volume":"18","author":[{"given":"Necmi","family":"Arslan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selda","family":"Kargin Kaytez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramazan","family":"Ocal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nihat","family":"Yumusak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"\u015eenes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Ibas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"55248","published-online":{"date-parts":[[2022,5,16]]},"container-title":["The Journal of International Advanced Otology"],"original-title":[],"link":[{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/download\/1634\/1632","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/download\/1617\/1614","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/download\/1617\/1614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T10:36:40Z","timestamp":1769078200000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/view\/1617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,16]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,5,16]]}},"URL":"https:\/\/doi.org\/10.5152\/iao.2022.20116","relation":{},"ISSN":["2148-3817"],"issn-type":[{"value":"2148-3817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,16]]}}}