{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:40:23Z","timestamp":1770338423963,"version":"3.49.0"},"reference-count":0,"publisher":"Caleo","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Adv Otol."],"abstract":"<jats:p>BACKGROUND: This study evaluated whether recovery from facial paralysis was associated with the expression of Krox-20 and c-Jun genes that are shown to be related to facial nerve regeneration after facial nerve compression and cutting.\n\nMETHODS: The left facial nerves of 24 male Sprague\u2013Dawley rats aged 6 weeks were subjected to crushing or cutting injury. Whisker movements of the vibrissae muscle and blink reflexes of the eyelids were measured on days 4 and 14 after facial nerve injury. The facial nerves on both sides were removed, and the expression of c-Jun and Krox-20 proteins was evaluated by Western blotting.\n\nRESULTS: The level of expression of Krox-20 on day 4 was lower in the crushing group, especially in the cutting group than in the control group (P &lt; .05), but there was no statistically significant difference on day 14 (P &gt; .05). The expression of c-Jun expression was significantly higher in the crushing and cutting groups than in the control group on days 4 and 14 (P &lt; .05).\n\nCONCLUSION: The degree of facial paralysis was more severe and the recovery rate was lower in the cutting group than in the crushing group. The levels of expression of Krox-20 and c-Jun were associated with facial nerve regeneration after facial nerve injury.\n\nCite this article as: Hyeok Kim I, Min Lee J, Yang Jung J,\u00a0et\u00a0al. Expression of c-jun and KROX-20 following facial nerve injury and recovery in rats. J Int Adv Otol. 2022;18(5):420-425.<\/jats:p>","DOI":"10.5152\/iao.2022.21367","type":"journal-article","created":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T08:41:23Z","timestamp":1660552883000},"page":"420-425","source":"Crossref","is-referenced-by-count":4,"title":["Expression of c-Jun and KROX-20 Following Facial Nerve Injury and Recovery in Rats"],"prefix":"10.65717","volume":"18","author":[{"given":"In","family":"Hyeok Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae","family":"Min Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yang Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwa","family":"Sung Rim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae","family":"Woong Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung","family":"Geun Yeo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"55248","published-online":{"date-parts":[[2022,8,12]]},"container-title":["The Journal of International Advanced Otology"],"original-title":[],"link":[{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/download\/1664\/1662","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/download\/1650\/1647","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/download\/1650\/1647","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T10:01:30Z","timestamp":1769076090000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/view\/1650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,12]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,9,1]]}},"URL":"https:\/\/doi.org\/10.5152\/iao.2022.21367","relation":{},"ISSN":["2148-3817"],"issn-type":[{"value":"2148-3817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,12]]}}}