{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T01:56:50Z","timestamp":1769133410410,"version":"3.49.0"},"reference-count":0,"publisher":"Caleo","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Adv Otol."],"abstract":"<jats:p>Background:\u00a0This study aims to elucidate the potential protective effects of Pycnogenol\u00ae against noise-induced hearing (NIHL) loss in a rat model.\nMethods:\u00a0This study employed a randomized controlled design to investigate the potential protective effects of Pycnogenol\u00ae against NIHL in a rat model. Twenty-five male Wistar albino rats were randomly assigned to 5 groups (n=5 per group): a control group receiving saline administration, a noise exposure group, a noise+saline receiving group, only Pycnogenol\u00ae receiving group, and finally, a Pycnogenol\u00ae treatment group receiving daily oral administration of Pycnogenol\u00ae at 40 mg\/kg\/day via gavage for 7 days following noise exposure. All groups were subjected to auditory brainstem response assessments at 4 time points: pre-exposure (baseline), post-exposure day 1, day 7, and day 21. Both noise exposure and the Pycnogenol\u00ae treatment groups were exposed to 4 kHz narrowband noise at 120 dB SPL for 4 hours. Following sacrifice, histological and immunohistochemical evaluations were conducted on cochlear tissues. Statistical analyses were performed using SPSS software version 25 to determine significant differences between groups and across time points.\nResults:\u00a0Outcome of this research shows that the auditory brainstem response thresholds and cochlear morphology between the experimental and control groups are significantly different from each other, suggesting that Pycnogenol\u00ae may have the potential to prevent NIHL loss in rats.\nConclusion: Pycnogenol\u00ae shows potential in protecting against NIHL. However, further research, particularly at the molecular level, is necessary to better understand its therapeutic mechanisms and its specific impact on auditory metabolic processes.<\/jats:p>","DOI":"10.5152\/iao.2025.241623","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T01:58:12Z","timestamp":1738288692000},"page":"1-7","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Pycnogenol\u00ae on Noise-Induced Hearing Loss in Rats"],"prefix":"10.65717","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4266-6332","authenticated-orcid":false,"given":"Seher","family":"Y\u0131lmaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9172-6269","authenticated-orcid":false,"given":"Caner","family":"Yatmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9022-8209","authenticated-orcid":false,"given":"Furkan","family":"B\u00fcy\u00fckkal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9491-8220","authenticated-orcid":false,"given":"Alev","family":"Cumbul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7380-4566","authenticated-orcid":false,"given":"I\u015f\u0131lay","family":"\u00d6z","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5985-097X","authenticated-orcid":false,"given":"M. B\u00fclent","family":"\u015eerbet\u00e7io\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"55248","published-online":{"date-parts":[[2025,1,27]]},"container-title":["The Journal of International Advanced Otology"],"original-title":[],"link":[{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/download\/1876\/1874","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/download\/1931\/1922","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/download\/1931\/1922","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T09:51:01Z","timestamp":1769075461000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/view\/1931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,27]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,27]]}},"URL":"https:\/\/doi.org\/10.5152\/iao.2025.241623","relation":{},"ISSN":["2148-3817"],"issn-type":[{"value":"2148-3817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,27]]}}}