{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T18:54:20Z","timestamp":1781722460636,"version":"3.54.5"},"reference-count":0,"publisher":"Caleo","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Adv Otol"],"abstract":"<jats:p>BACKGROUND: Sudden deafness (SD) is defined as unexplained hearing loss of at least 30 decibels (dB) occurring within 72 hours over at least 3 contiguous frequencies, with idiopathic etiology that may be influenced by genetic factors. This study aimed to investigate the association between the rs5746105 polymorphism of the superoxide dismutase 2 (SOD2) gene and SD.\r\nMETHODS: In this study, 150 patients diagnosed with SD were consecutively recruited and 150 healthy individuals were selected as controls. The genotyping of the SOD2 rs5746105 polymorphism was performed using the PCR-RFLP method. The Hardy-Weinberg equilibrium test was applied to evaluate the distribution of gene and genotype frequencies. Logistic regression analysis was conducted to identify potential independent risk factors for SD.\r\nRESULTS: Smoking, hypertension, diabetes, total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) were significantly associated with the onset of SD (P &lt; .05). The SOD2 rs5746105 gene polymorphism was also linked to SD. Specifically, the A allele (P = .017, OR = 1.485, 95% CI: 1.073-2.055) and the GA\/AA genotypes (P = .015, OR =2.149, 95% CI: 1.152-4.009) were associated with an increased risk of SD. In patients with SD and mild hearing impairment, the AA genotype (P = .029, OR = 2.473, 95% CI: 1.164-5.249) may be a significant risk factor. Logistic regression analysis identified smoking, hypertension, and the rs5746105 polymorphism as independent risk factors for SD (P &lt; .05).\r\nCONCLUSION: The rs5746105 polymorphism in the SOD2 gene was associated with an increased susceptibility to SD.<\/jats:p>","DOI":"10.5152\/iao.2025.251995","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T19:09:16Z","timestamp":1780600156000},"page":"1-5","source":"Crossref","is-referenced-by-count":0,"title":["The Genetic Association of rs5746105 Polymorphism of SOD2 with the Susceptibility to Sudden Deafness"],"prefix":"10.65717","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2449-6798","authenticated-orcid":false,"given":"Fang","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0361-0631","authenticated-orcid":false,"given":"Hongyan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8401-4990","authenticated-orcid":false,"given":"Fang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5814-4005","authenticated-orcid":false,"given":"Shasha","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0703-5590","authenticated-orcid":false,"given":"Congcong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7207-9163","authenticated-orcid":false,"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"55248","published-online":{"date-parts":[[2025,12,26]]},"container-title":["The Journal of International Advanced Otology"],"original-title":[],"link":[{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/download\/1944\/1931","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/download\/1944\/1931","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T18:40:49Z","timestamp":1781721649000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/view\/1944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,26]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,1,2]]}},"URL":"https:\/\/doi.org\/10.5152\/iao.2025.251995","relation":{},"ISSN":["2148-3817"],"issn-type":[{"value":"2148-3817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,26]]}}}