{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T18:54:08Z","timestamp":1781722448592,"version":"3.54.5"},"reference-count":0,"publisher":"Caleo","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Adv Otol"],"abstract":"<jats:p>BACKGROUND: The study aims to demonstrate the possible protective effects of carbon monoxide\u2013releasing molecule-3 (CORM-3) on the auditory system after noise exposure through electrophysiological measurements and histopathological methods.\r\nMETHODS: Twenty-four albino Wistar male rats were included in the study. They were equally divided into 3 groups. The control group was administered intraperitoneal physiological saline for 7 days. Eight rats in the second group were exposed to 4 kHz octave band noise at 120 dB SPL intensity for 4 hours, and then intraperitoneal saline was administered for 7 days. Group 3, after exposure to noise with the same characteristics, was administered 10 mg\/kg of CORM-3 intraperitoneally for 7 days. Hearing levels were measured at baseline, on the first, and seventh days with distortion product otoacoustic emissions (DPOAEs) and auditory evoked brainstem potentials at 4, 6, and 8 kHz. After the measurements, the cochlear structures of all rats were dissected, and the cochlear structures were evaluated by light microscopy.\r\nRESULTS: Auditory evoked brainstem potential test results showed that the CORM-3 group had better hearing thresholds at all frequencies than the other group exposed to noise. These findings were statistically significant (P &lt; .05). The DPOAE responses disappeared after acoustic trauma. Histopathological evaluation showed cellular damage caused by noise in the cochlea.\r\nCONCLUSION: The findings suggest that CORM-3 may be an effective protective and therapeutic agent against noise-induced hearing loss. However, additional research is needed to prove this protective effect.<\/jats:p>","DOI":"10.5152\/iao.2025.252110","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T19:09:16Z","timestamp":1780600156000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Carbon Monoxide\u2013Releasing Molecule-3 on Auditory and Histopathological Outcomes in Rats Exposed to Acoustic Trauma: A Study of Antioxidant and Cytoprotective Pathways"],"prefix":"10.65717","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9134-3070","authenticated-orcid":false,"given":"Ilda Tanrisever","family":"Pehlivan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5041-2802","authenticated-orcid":false,"given":"Ozgur","family":"Surmelioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4433-0194","authenticated-orcid":false,"given":"Caglar","family":"Eker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1018-3464","authenticated-orcid":false,"given":"Elvan","family":"Onan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1923-3731","authenticated-orcid":false,"given":"Muhammed","family":"Dagkiran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6301-0308","authenticated-orcid":false,"given":"Leman","family":"Sencar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5055-4226","authenticated-orcid":false,"given":"Dilek","family":"Saker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"55248","published-online":{"date-parts":[[2025,12,26]]},"container-title":["The Journal of International Advanced Otology"],"original-title":[],"link":[{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/download\/1950\/1938","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/download\/1950\/1938","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T18:40:23Z","timestamp":1781721623000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/view\/1950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,26]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,1,2]]}},"URL":"https:\/\/doi.org\/10.5152\/iao.2025.252110","relation":{},"ISSN":["2148-3817"],"issn-type":[{"value":"2148-3817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,26]]}}}