{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T09:05:18Z","timestamp":1775639118845,"version":"3.50.1"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AOTT"],"abstract":"<jats:p>Objective: The risk of symptomatic venous thromboembolism (VTE) following hip fracture surgery is estimated at 1%-6%, necessitating effective prophylactic measures. While aspirin has been widely used in total hip and knee arthroplasty due to its comparable efficacy, reduced bleeding risk, and cost-effectiveness, its role in trauma patients remains under researched. This study aims to evaluate the efficacy and safety of aspirin and enoxaparin for VTE prophylaxis in hip fracture patients.\r\nMethods: This two-center, retrospective study analyzed 306 adult patients who underwent hip fracture surgery between 2019 and 2023. Patients were divided into 2 groups: the aspirin group (81 mg twice daily) and the enoxaparin group (40 mg subcutaneous once daily), both receiving prophylaxis for 4 weeks postoperatively. Demographics, comorbidities, surgical details, and clinical outcomes\u2014including major bleeding events, symptomatic VTE (deep vein thrombosis and pulmonary embolism), periprosthetic joint infection (PJI), blood transfusion requirements, and 90-day mortality\u2014were recorded. Statistical analyses were performed using Pearson chi-square and independent t-tests, with significance set at P &lt; .05.\r\nResults: The aspirin group (n = 136) and enoxaparin group (n = 170) had mean ages of 67.66 \u00c5} 19.67 and 63.42 \u00c5} 19.71 years, respectively. Hemoglobin decrease was significantly lower in the aspirin group (1.75 \u00c5} 1.07 g\/dL vs. 2.73 \u00c5} 1.56 g\/dL, P = .001). In addition, the amount of postoperative blood transfusion was statistically significantly lower in the aspirin group compared to in the enoxaparin group (0.89 vs. 1.31 units, respectively, P = .034). There was no significant difference in mean hospital stay (6.84 vs. 6.65 days, P = .751). The incidence of major bleeding was higher in the enoxaparin group (3.7% (n = 5) vs. 5.3% (n = 9)), though not statistically significant (P = .789). Symptomatic VTE occurred in 3.7% (n = 5) of the aspirin group and 5.3% (n = 9) of the enoxaparin group (P = .453). Periprosthetic joint infection was observed in 2 patients in the enoxaparin group but none in the aspirin group (P = .447). Mortality within 90 days was lower in the aspirin group (8.8% (n = 12) vs. 15.9% (n = 27)), but the difference was not statistically significant (P = .066).\r\n Conclusion: This study suggests that aspirin appears to be a reasonable alternative to enoxaparin for VTE prophylaxis in hip fracture patients, demonstrating comparable efficacy with a lower blood transfusion requirement and similar rates of major bleeding and symptomatic VTE. Given its affordability, ease of administration, and favorable safety profile, aspirin appears to be a reasonable and costeffective alternative for high-risk trauma patients.\r\n\u00a0\r\nCite this article as: Korkmaz O, Hakyemez \u00d6S, \u00c7ak\u0131r N, et al. Comparison of clinical outcomes of enoxaparin and aspirin for postoperative venous thromboembolism prophylaxis in hip fractures. Acta Orthop Traumatol Turc. 2026; 60(2), 0305, doi: 10.5152\/j.aott.2026.25305.<\/jats:p>","DOI":"10.5152\/j.aott.2026.25305","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T08:26:03Z","timestamp":1775636763000},"source":"Crossref","is-referenced-by-count":0,"title":["Comparison of clinical outcomes of enoxaparin and aspirin for postoperative venous thromboembolism prophylaxis in hip fractures"],"prefix":"10.5152","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9649-5199","authenticated-orcid":false,"given":"O\u011fuzhan","family":"Korkmaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1448-2656","authenticated-orcid":false,"given":"\u00d6mer Serdar","family":"Hakyemez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9858-1450","authenticated-orcid":false,"given":"Niyazi","family":"\u00c7ak\u0131r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1278-4592","authenticated-orcid":false,"given":"Ardahan","family":"\u00d6zdenboyac\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3796-3622","authenticated-orcid":false,"given":"\u0130brahim","family":"Uzunlu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0833-0752","authenticated-orcid":false,"given":"Abdullah","family":"Demirta\u015f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0926-3029","authenticated-orcid":false,"given":"\u0130brahim","family":"Azboy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2026,3,27]]},"container-title":["Acta Orthopaedica et Traumatologica Turcica"],"original-title":[],"link":[{"URL":"https:\/\/www.aott.org.tr\/index.php\/pub\/article\/download\/4124\/4074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.aott.org.tr\/index.php\/pub\/article\/download\/4124\/4074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T08:26:03Z","timestamp":1775636763000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aott.org.tr\/index.php\/pub\/article\/view\/4124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,27]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,3,4]]}},"URL":"https:\/\/doi.org\/10.5152\/j.aott.2026.25305","relation":{},"ISSN":["2589-1294","1017-995X"],"issn-type":[{"value":"2589-1294","type":"electronic"},{"value":"1017-995X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,27]]}}}