{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:33:06Z","timestamp":1777375986747,"version":"3.51.4"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Gastroenterology"],"abstract":"<jats:p>Abstract Background\/Aims: Chromogranin A is an important tool in the diagnosis of neuroendocrine tumors. Autoimmune gastritis is an autoimmune disorder marked by hypergastrinemia, which stimulates enterochromaffin-like cell proliferation. Chromogranin A is also elevated in autoimmune gastritis patients with a different level of increase in each patient. The goal of this study is to explore constituents that influence serum chromogranin A levels in autoimmune gastritis patients. Materials and Methods: One hundred and eighty-eight autoimmune gastritis patients and 20 patients with type I gastric carcinoid tumors were analyzed retrospectively and compared to 110 functional dyspepsia patients in terms of factors that might affect serum chromogranin A levels. Results: The mean serum chromogranin A level was 171.17&amp;plusmn;67.3 ng\/mL in autoimmune gastritis patients (n=62) without enterochromaffin-like cell hyperplasia, and 303.3&amp;plusmn;102.82 ng\/mL in patients (n=126) with enterochromaffin-like cell hyperplasia (p&amp;lt;0.001). The presence of corpus atrophy (p=0.026, OR: 5.03, CI 95%: 1.21&amp;ndash;20.88, &amp;beta;=1.61) and presence of enterochromaffin-like cell hyperplasia (p=0.017, OR: 6.59, CI 95%: 1.4&amp;ndash;31.08, &amp;beta;=1.88) were found as risk factors associated with serum chromogranin A level. Conclusion: Factors influencing raised serum chromogranin A levels in autoimmune gastritis were the presence of ECL cell hyperplasia and serum gastrin levels. Serum chromogranin A levels maybe helpful in distinguishing autoimmune gastritis patients and gastric carcinoid type I from the control group, but not useful in the differentiation of individuals with autoimmune gastritis from patients with gastric carcinoids.<\/jats:p>","DOI":"10.5152\/tjg.2016.16486","type":"journal-article","created":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T07:40:55Z","timestamp":1479109255000},"page":"515-520","source":"Crossref","is-referenced-by-count":5,"title":["Factors associated with elevated serum chromogranin A levels  in patients with autoimmune gastritis"],"prefix":"10.5152","volume":"27","author":[{"given":"\u00c7a\u011fda\u015f","family":"Kalkan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih","family":"Karakaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130rfan","family":"Soykan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2016,11,15]]},"container-title":["Turkish Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/download\/2981\/2659","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:03:41Z","timestamp":1777367021000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/view\/2981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,15]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,11,15]]}},"URL":"https:\/\/doi.org\/10.5152\/tjg.2016.16486","relation":{},"ISSN":["2148-5607"],"issn-type":[{"value":"2148-5607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,15]]}}}