{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:04:51Z","timestamp":1792587891440,"version":"4.5.0"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Gastroenterology"],"abstract":"<jats:p>Abstract Proton pump inhibitors (PPIs) are the most effective agents in the first-line and maintenance treatment of gastroesophageal reflux disease. As the grade of esophagitis increases, an increase is also observed in the level of endoscopic response to PPIs. In the first-line therapy of patients with severe esophagitis (Los Angeles (LA) Grade C-D), administration of a standard dose of PPIs bid has been reported to be more beneficial than PPIs qd. While any intermittant and low dose-continuous treatment can be chosen for the maintenance therapy of patients with non-erosive reflux disease or mild esophagitis (LA Grade A-B), continuous use of a standard dose of PPIs is preferred in the maintenance therapy of patients with severe esophagitis (LA Grade C-D). In patients who use PPIs for a long time, the drug must be stopped by gradually decreasing the dose. Cite this article as: Bor S, Kalkan \u0130H. Medical treatment of gastroesophageal reflux disease. Turk J Gastroenterol 2017;28(Suppl 1); S48-S52 Full Text Turkish<\/jats:p>","DOI":"10.5152\/tjg.2017.13","type":"journal-article","created":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T01:27:33Z","timestamp":1512091653000},"page":"S48-S52","source":"Crossref","is-referenced-by-count":3,"title":["Medical treatment of gastroesophageal reflux disease"],"prefix":"10.5152","volume":"28","author":[{"given":"Serhat","family":"Bor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130smail Hakk\u0131","family":"Kalkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2017,1,15]]},"container-title":["Turkish Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/download\/3008\/2686","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:27:14Z","timestamp":1773329234000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/view\/3008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,15]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,15]]}},"URL":"https:\/\/doi.org\/10.5152\/tjg.2017.13","relation":{},"ISSN":["2148-5607"],"issn-type":[{"value":"2148-5607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,15]]}}}