{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T12:20:48Z","timestamp":1781180448704,"version":"3.54.1"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Gastroenterology"],"abstract":"<jats:p>Background\/Aims: Small intestinal bacterial overgrowth (SIBO) and hemodynamic changes are common in cirrhosis. We wanted to examine our hypothesis whether SIBO leads to hemodynamic changes in cirrhosis.\n\nMaterials and Methods: A total of 50 patients with cirrhosis and 15 healthy controls were enrolled in a pilot prospective study. All participants underwent the lactulose hydrogen breath test for SIBO and echocardiography with a simultaneous assessment of blood pressure and heart rate. Cardiac output and systemic vascular resistance were calculated.\n\nResults: Study participants with SIBO had a lower systolic blood pressure and systemic vascular resistance compared to those without SIBO and to healthy controls (110.2\u00b112.3 mmHg vs. 126.2\u00b121.0 mmHg and 121.2\u00b19.8 mmHg; p=0.005 and p=0.011, respectively; 1312\u00b1352 dyn\u2022s\u2022cm\u22125 vs. 1704\u00b1424 dyn\u2022s\u2022cm\u22125 and 1648\u00b1272 dyn\u2022s\u2022cm\u22125; p=0.001 and p=0.006, respectively), but a higher cardiac output (5.38\u00b11.41 l\/min vs. 4.52\u00b11.03 l\/min and 4.40\u00b10.68 l\/min; p=0.034 and p=0.041, respectively) and C-reactive protein (10.5[1.2-16.5] mg\/l vs. 2.8[0.6-9.1] mg\/l; p=0.028; no comparison with healthy controls). There were no significant differences between patients without SIBO and healthy controls with regard to systolic blood pressure (p=0.554), systemic vascular resistance (p=0.874), and cardiac output (p=0.795). SIBO was associated with vasodilation and hyperdynamic circulation in decompensated cirrhosis (p=0.002; p=0.012), but not in compensated cirrhosis (p=1.000; p=0.474).\n\nConclusions: SIBO is associated with hyperdynamic circulation and other hemodynamic changes in cirrhosis and may be a principal factor causing these through systemic inflammation.<\/jats:p>","DOI":"10.5152\/tjg.2019.18551","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T03:15:25Z","timestamp":1574392525000},"page":"964-975","source":"Crossref","is-referenced-by-count":19,"title":["Is small intestinal bacterial overgrowth a cause of hyperdynamic circulation in cirrhosis?"],"prefix":"10.5152","volume":"30","author":[{"given":"Roman","family":"Maslennikov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chavdar","family":"Pavlov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Ivashkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2019,11,15]]},"container-title":["Turkish Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/download\/3511\/3174","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T12:12:51Z","timestamp":1773231171000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/view\/3511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,15]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,11,15]]}},"URL":"https:\/\/doi.org\/10.5152\/tjg.2019.18551","relation":{},"ISSN":["2148-5607"],"issn-type":[{"value":"2148-5607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,15]]}}}