{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:33:06Z","timestamp":1790940786809,"version":"4.1.0"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Gastroenterology"],"abstract":"<jats:p>Background and Aims: Chronic hepatitis B is an important health problem in all countries. I Interferon gamma is a pro-inflammatory Th1 cytokines, which can exert antiproliferative and antitumor activity. Some SNPs in IFN-\u03b3 and IFN-\u03b3R1 genes may influence the susceptibility to HBV. Here, we evaluated the impact of interferon gamma (+874 T\/A) and its receptor (-611A\/G, +189G\/C and +95C\/T) polymorphisms and the risk of HBV in Iranian patients.\n\n\n\nMaterials and Methods: SNPs of interferon gamma and its receptor genotypes were determined in 221 infected patients with HBV and 200 people without HBV using ARMS-PCR and PCR- RFLP method.\n\n\n\nResults: In this study, we showed an obvious relationship between IFN-\u03b3 SNPs and susceptibility to chronic HBV. Our findings suggest that IFN-\u03b3-874A allele increases the risk of disease and carriers of the T allele have reduced susceptibility to infection. In addition, there was not any relationship between the -611A\/G, +189G\/C and +95C\/T regions of IFN-\u03b3 R1 and HBV.\n\n\n\nConclusions: Our observations demonstrate +874 T\/A SNP as a predicting factor in patients who have the risk of HBV.<\/jats:p>","DOI":"10.5152\/tjg.2020.181024","type":"journal-article","created":{"date-parts":[[2020,5,3]],"date-time":"2020-05-03T15:55:51Z","timestamp":1588521351000},"page":"515-521","source":"Crossref","is-referenced-by-count":5,"title":["Interferon gamma gene polymorphisms and chronic hepatitis B infections in an Iranian population"],"prefix":"10.5152","volume":"31","author":[{"given":"Zahra","family":"Heidari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bita","family":"Moudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamidreza","family":"Mahmoudzadeh-Sagheb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2020,7,15]]},"container-title":["Turkish Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/download\/3604\/3267","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T11:41:29Z","timestamp":1773229289000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/view\/3604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,15]]},"references-count":0,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,7,15]]}},"URL":"https:\/\/doi.org\/10.5152\/tjg.2020.181024","relation":{},"ISSN":["2148-5607"],"issn-type":[{"value":"2148-5607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,15]]}}}