{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T07:20:54Z","timestamp":1775028054152,"version":"3.50.1"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Gastroenterology"],"abstract":"<jats:p>Background\/Aims: Analysis of genes thought to be important in IBD have shown that  more than half of IBD-related genes are also associated with other autoimmune diseases. The aim of this study was to detect a possible association between the polymorphisms of the (-670 A\/G, -1377 G\/A) FAS gene promoter and susceptibility to IBD in the Turkish population. \n\nMaterials and Methods: 125 patients with IBD including 73 ulcerative colitis and 52 Crohn's disease and also 101 healthy controls without any pathological signs of IBD. Real-time PCR technique was used to detect FAS polymorphisms in this study. \n\nResults: Analysis of FAS -670 A\/G polymorphism indicated that frequency of GG genotype was increased in patients compared to controls significantly (p&lt;0.001). Also, AG genotype (p&lt;0.001) and A allele (p&lt;0.001) frequencies were higher in controls than patients. Analysis of FAS -1377 G\/A polymorphism revealed that frequency of AA genotype was increased in patients compared to controls meaningfully (p&lt;0.001). Additionally, GG genotype (p&lt;0.001) and G allele (p&lt;0.001) frequencies were increased in controls when compared to patients. \n\nConclusion: FAS -670A\/G GG genotype seemed to be as a protective allele against to IBD, however AA genotype and A allele were associated with elevated risk of IBD. In the FAS -1377G\/A polymorphism, frequencies of the G allele and GG genotype were observed to be protective against IBD whereas AA, GA genotypes, and A allele frequency increased in the patient group.<\/jats:p>","DOI":"10.5152\/tjg.2020.19436","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T14:04:59Z","timestamp":1588601099000},"page":"356-361","source":"Crossref","is-referenced-by-count":8,"title":["The role of FAS gene variants in inflammatory bowel disease"],"prefix":"10.5152","volume":"31","author":[{"given":"Ayhan","family":"Demir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Resul","family":"Kahraman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonca","family":"Candan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arzu","family":"Ergen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2020,5,15]]},"container-title":["Turkish Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/download\/3582\/3245","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T11:40:20Z","timestamp":1773229220000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/view\/3582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,15]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,5,15]]}},"URL":"https:\/\/doi.org\/10.5152\/tjg.2020.19436","relation":{},"ISSN":["2148-5607"],"issn-type":[{"value":"2148-5607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,15]]}}}