{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:41:20Z","timestamp":1791477680744,"version":"4.3.4"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Gastroenterology"],"abstract":"<jats:p>Background\/Aims: This study aimed to explore the therapeutic effects and underlying mechanism of berberine (BBR) on the non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet (HFD).\n\nMaterials and Methods: Rats were randomly divided into the following 4 groups: control (normal diet), model (HFD), polyene phosphatidylcholine HFD+PPC, and BBR (HFD+BBR) group. The NAFLD models were prepared by feeding with HFD for 12 weeks. The liver tissues were observed by oil red O staining. H&amp;E staining was used to detect pathological changes in the liver tissues. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were detected by an automatic biochemical analyzer. ELISA was performed to observe the inflammatory cytokines (TNF-\u03b1, IL-6, and IL-1\u03b2) expressions. The levels of TLR4, MyD88, and NF-\u03baB p65 were analyzed using western blot and qRT-PCR, respectively. The nuclear translocation levels of NF-\u03baB in the primary liver cells were measured using flow cytometry.\n\nResults: BBR could significantly alleviate the liver tissue steatosis and inflammatory cell infiltration; reduce the NAFLD activity scores and serum levels of ALT, AST, TC, and LDL-C; decrease the levels of TNF-\u03b1, IL-6, and IL-1\u03b2, and reduce the expression of TLR4, MyD88, and NF-\u03baB in the liver tissues. BBR could also reverse the nuclear translocation of NF-\u03baB in the primary liver cells.\n\nConclusion: BBR alleviated the progress of NAFLD and liver damage, which might contribute to inhibit the nuclear translocation of NF-\u03baB via the TLR4\/MyD88\/NF-\u03baB pathway.<\/jats:p>","DOI":"10.5152\/tjg.2020.19568","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T20:28:53Z","timestamp":1588624133000},"page":"902-909","source":"Crossref","is-referenced-by-count":46,"title":["Berberine inhibits liver damage in rats with non-alcoholic fatty liver disease by regulating TLR4\/MyD88\/NF-\u03baB pathway"],"prefix":"10.5152","volume":"31","author":[{"given":"Lingling","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhandong","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangcai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2020,12,15]]},"container-title":["Turkish Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/turkjgastroenterol.org\/index.php\/tjg\/article\/download\/3666\/3329","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T09:19:01Z","timestamp":1773220741000},"score":1,"resource":{"primary":{"URL":"https:\/\/turkjgastroenterol.org\/index.php\/tjg\/article\/view\/3666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,15]]},"references-count":0,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12,15]]}},"URL":"https:\/\/doi.org\/10.5152\/tjg.2020.19568","relation":{},"ISSN":["2148-5607"],"issn-type":[{"value":"2148-5607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,15]]}}}