{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:12:29Z","timestamp":1773281549692,"version":"3.50.1"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Gastroenterology"],"abstract":"<jats:p>Background: Hepatitis-associated aplastic anemia (HAAA) is a rare complication that presented with bone marrow failure after acute\n\nhepatitis. HAAA usually occurs in adolescent men within 1-6 months following hepatitis. Most of HAAA\u2019s etiology has non-A-E viral\n\nhepatitis.\n\nMethods: Our retrospective study included patients with acute fulminant hepatitis who had been treated in Ege University Pediatric\n\nGastroenterology, Hepatology and Nutrition Department and \u0130zmir Kent Hospital Clinical, laboratory, and epidemiological data of the\n\npatients were collected from the files.\n\nResults: In this study, 499 children underwent liver transplantation (LT) in two pediatric transplantation centers. Sixty-eight (13.6%)\n\nout of 499 patients, underwent liver transplantation due to fulminant hepatic failure (FHF). Therefore, a total of 64 patients (34 girls,\n\n30 boys) with a diagnosis of FHF have included in the study. Thirty-two (50.0%) of 64 FHF were due to non-A-E hepatitis and 4 out of the\n\n64 patients (6.2%) with FHF developed HAAA. All of the patients received prednisolone as immunosuppression treatment after LT. Three\n\npatients were also given Tacrolimus and 1 received an additional mycophenolate mofetil. One of the patients was given prednisolone\n\nand cyclosporine treatment without tacrolimus. Bone marrow transplantation was performed in 1 patient (25.0%). Two of the patients\n\nreceived immunosuppressive treatment including rabbit-derived anti-thymocyte globulin, cyclosporine, and initially prednisolone.\n\nConclusion: In children who underwent liver transplantation for non-A-E FHF are at high risk to develop aplastic anemia. The clinicians\n\nshould be alert after orthotropic liver transplantation patient could develop aplastic anemia and early treatment with immunosuppressive\n\ntherapies result in a more successful outcome.<\/jats:p>","DOI":"10.5152\/tjg.2021.20150","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T08:09:41Z","timestamp":1623398981000},"page":"313-317","source":"Crossref","is-referenced-by-count":1,"title":["Aplastic Anemia Frequency and Management in Pediatric Liver Transplantations Due to Non-A-E Hepatitis"],"prefix":"10.5152","volume":"32","author":[{"given":"Ezgi","family":"K\u0131ran Ta\u015fc\u0131","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miray","family":"Karakoyun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nihal","family":"\u00d6zdemir Karada\u015f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamiyet","family":"Hekimci \u00d6zdemir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz Y\u0131lmaz","family":"Karap\u0131nar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can","family":"Karaca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Funda","family":"\u00c7etin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sema","family":"Aydo\u011fdu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2021,3,15]]},"container-title":["Turkish Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/download\/3718\/3381","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T11:19:38Z","timestamp":1773227978000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/view\/3718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,15]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,3,15]]}},"URL":"https:\/\/doi.org\/10.5152\/tjg.2021.20150","relation":{},"ISSN":["2148-5607"],"issn-type":[{"value":"2148-5607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,15]]}}}