{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:13:19Z","timestamp":1788581599859,"version":"build-2803163510"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Gastroenterology"],"abstract":"<jats:p>Background: It is known that clarithromycin resistance has increased over the years (success rate 60%). The aim of the study was to\n\ninvestigate the importance of regional antimicrobial resistance rates for full accuracy of both diagnosis and treatment of Helicobacter\n\npylori infection.\n\nMethods: This study was carried out in the University Hospital Department of Gastroenterology. A total of 116 patients were evaluated\n\nwith upper gastrointestinal endoscopy. Gastric antrum and corpus biopsy samples were taken for the rapid urease test (RUT), culture,\n\nand antimicrobial susceptibility testing for the presence of H. pylori. Antimicrobial susceptibilities of isolated H. pylori strains for clarithromycin\n\nand levofloxacin were determined by the epsilometer test (E-test). Minimal inhibitory concentration values for clarithromycin\n\nand levofloxacin were \u22651 and &gt;1 \u03bcg\/mL, respectively.\n\nResults: H. pylori infection was considered clinically positive in 93 (80.2%) patients with either the RUT, culture, or histopathological\n\nexamination. Seventy (60.3%) of the patients had RUT positivity. Sixty (85.7%) of these 70 patients had RUT positivity within the first\n\n20 min. Among the 90 patients, who had a histopathological examination, HLO was positive in 76 (84.4%) patients. Fifty-two (44.8%)\n\nout of 116 patients were culture positive. Resistance rates for both clarithromycin and levofloxacin were high. In these 52 culture-positive\n\npatients, resistance rates determined for clarithromycin and levofloxacin were 26.9% and 25.5%, respectively.\n\nConclusion: Clarithromycin or levofloxacin-based treatment regimen may not be an ideal alternative therapy for Turkish patients\n\nregardless of culture.<\/jats:p>","DOI":"10.5152\/tjg.2021.20210","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T08:09:41Z","timestamp":1623398981000},"page":"269-275","source":"Crossref","is-referenced-by-count":4,"title":["Unacceptable Antibiotic Resistance Rates for Helicobacter pylori in Turkey: Something Must Change"],"prefix":"10.5152","volume":"32","author":[{"given":"Bilge M\u00fcge","family":"G\u00f6k\u00e7ekuyu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00fcjde","family":"Soyt\u00fcrk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fclya","family":"Ellidokuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hale","family":"Akp\u0131nar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lkay","family":"\u015eim\u015fek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2021,3,15]]},"container-title":["Turkish Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/download\/3713\/3376","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T11:19:43Z","timestamp":1773227983000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/view\/3713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,15]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,3,15]]}},"URL":"https:\/\/doi.org\/10.5152\/tjg.2021.20210","relation":{},"ISSN":["2148-5607"],"issn-type":[{"value":"2148-5607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,15]]}}}