{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T07:13:58Z","timestamp":1793258038967,"version":"4.5.0"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Gastroenterology"],"abstract":"<jats:p>Background: In chronic diarrhea patients, massive over-reporting symptom-based criteria for functional bowel disorders are pitfalls.\n\nThere is currently no objective biomarker that may provide a correct correlation with the severity of chronic diarrhea. To clarify the role of\n\nfibroblast growth factor-19 (FGF-19) as a biomarker of objective measurements of the severity of diarrhea in comparison with a patientreported\n\noutcome, based on the Bristol Stool Form (BSF) Scale.\n\nMethods: Consecutive 100 patients with chronic diarrhea underwent standard investigations with laboratory tests, fecal calprotectin\n\n(FC), endoscopy with biopsies, and serum FGF-19. All patients and 14 healthy controls completed a diary recording, BSF, and stool\n\nfrequency.\n\nResults: We found that irritable bowel syndrome with diarrhea (IBS-D) n = 21\/23 (91%) reported a high number on BSF \u22656, compared\n\nto patients with inflammatory bowel diseases (IBD) 56\/77 (72%) with BSF \u2265 6 (P = .011). FGF-19 median serum levels were significantly\n\nlower in Microscopic colitis (0.010 pg\/mL) and IBD patients (0.009 pg\/mL) compare to IBS-D (266.9 pg\/mL) and high levels in healthy\n\nsubjects (463 pg\/mL) (P &lt; .001). Strong inverse correlation of FGF-19 with the stool frequency\/day and stool index was found (r = \u22120.800,\n\nP &lt; .001; r = \u22120.739, P &lt; .001), independently from disease activity (r = \u22120.718, P = .001; r = \u22120.792, P = .001).\n\nConclusion: Serum FGF-19 can become a new biomarker for evaluating the severity of diarrhea with objectively and independently from\n\nintestinal inflammation. FC and FGF-19 are predictive biomarkers for the organic cause of diarrhea.<\/jats:p>","DOI":"10.5152\/tjg.2021.20247","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T04:35:57Z","timestamp":1624509357000},"page":"374-381","source":"Crossref","is-referenced-by-count":10,"title":["Serum Levels of Fibroblast Growth Factor 19 Correlate with the Severity of Diarrhea and Independently from Intestinal Inflammation in Patients with Inflammatory Bowel Disease or Microscopic Colitis"],"prefix":"10.5152","volume":"32","author":[{"given":"Ivan","family":"Lyutakov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radislav","family":"Nakov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hristo","family":"Valkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rositsa","family":"Vatcheva-Dobrevska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borislav","family":"Vladimirov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Plamen","family":"Penchev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2021,4,15]]},"container-title":["Turkish Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/download\/3725\/3388","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T11:20:24Z","timestamp":1773228024000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/view\/3725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,15]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4,15]]}},"URL":"https:\/\/doi.org\/10.5152\/tjg.2021.20247","relation":{},"ISSN":["2148-5607"],"issn-type":[{"value":"2148-5607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,15]]}}}