{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T16:43:09Z","timestamp":1774629789436,"version":"3.50.1"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Gastroenterology"],"abstract":"<jats:p>Background: Essential phospholipids (EPL) are used as adjuvant treatment in people with fatty liver disease and other chronic liver\n\ndiseases. A new formulation of EPL paste was developed to improve patient compliance. The study was aimed to assess the safety,\n\npatient-reported outcomes, and impact on compliance of the new EPL paste formulation in patients with non-alcoholic fatty liver disease\n\n(NAFLD) or viral hepatitis.\n\nMethods: The study enrolled 147 patients (48.3% male; mean \u00b1 standard deviation (SD) age 44.8 \u00b1 10.5 years) in the intention-to-treat\n\npopulation; 72.8% had NAFLD and 27.9% had viral hepatitis B (HBV) or hepatitis C (HCV). Patients received EPL paste (one 600 mg\n\nsachet 3 times daily) for 12 weeks, with 4-, 8-, and 12-week scheduled visits and a 13-week follow-up visit. Patient-reported outcomes\n\nwere evaluated at 4, 8, and 12 weeks compared with baseline using dedicated Likert scales. Compliance was assessed by comparing\n\nactual versus prescribed dosing of the EPL.\n\nResults: After 12-week treatment with EPL paste, statistically significant improvements were observed in mean \u00b1 SD Global Overall\n\nSymptom scores (from 4.21 \u00b1 1.09 to 1.87 \u00b1 0.91; P &lt; .01) and overall Gastrointestinal Symptom scores (from 19.91 \u00b1 5.74 to 11.17 \u00b1 3.57;\n\nP &lt; .01), compared to baseline scores. Compliance with prescribed essential phospholipid treatment was 99% throughout the 12-week\n\ntreatment period.\n\nConclusion: Essential phospholipids paste had a favorable safety profile associated with improved gastrointestinal symptoms and with\n\nhigh levels of compliance in patients with NAFLD and viral hepatitis.<\/jats:p>","DOI":"10.5152\/tjg.2021.20294","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T03:58:01Z","timestamp":1632283081000},"page":"750-757","source":"Crossref","is-referenced-by-count":1,"title":["Safety and Effectiveness of Essential Phospholipids Paste in Patients with Non-alcoholic Fatty Liver Disease or Viral Hepatitis"],"prefix":"10.5152","volume":"32","author":[{"given":"Vladimir T.","family":"Ivashkin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor V.","family":"Maev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chavdar S.","family":"Pavlov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina V.","family":"Mayevskaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksey A.","family":"Samsonov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyudmila K.","family":"Palgova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirill M.","family":"Starostin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2021,9,15]]},"container-title":["Turkish Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/download\/3773\/3436","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T11:24:45Z","timestamp":1773228285000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/view\/3773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,15]]},"references-count":0,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,9,15]]}},"URL":"https:\/\/doi.org\/10.5152\/tjg.2021.20294","relation":{},"ISSN":["2148-5607"],"issn-type":[{"value":"2148-5607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,15]]}}}