{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T23:08:03Z","timestamp":1777158483585,"version":"3.51.4"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Gastroenterology"],"abstract":"<jats:p>Background: Wilson disease (WD) is an autosomal recessive inherited disorder of copper (Cu2+) metabolism, resulting in Cu2+ accumulation\n\nand liver and central nervous system toxicity. Oxidative stress may have a role in the pathogenesis of Wilson disease, but the roles\n\nof thiol\/disulfide homeostasis and nitrosative stress have not been examined. The purpose of this study was to evaluate whether there\n\nis a modification in thiol\/disulfide homeostasis and nitrosative stress in patients with Wilson disease.\n\nMethods: A total of 50 patients with Wilson disease (42 under drug treatment and 8 newly diagnosed patients with no drug treatment)\n\nand 50 healthy gender- and age-matched controls were enrolled for this study. Serum native thiol and total thiol levels were measured\n\nwith a spectrophotometric method. The number of disulfide bonds and the related ratios were determined from these measurements.\n\nSerum nitric oxide (NO) and 3-nitrotyrosine (3-NT) levels were analyzed using chemiluminescence and ELISA assays, respectively.\n\nResults: The average native thiol levels of the patient group under drug treatment were found to be markedly higher than the levels of\n\ncontrols (P &lt; .05). We detected no marked changes in total thiol and disulfide levels, and disulfide\/total thiol, disulfide\/native thiol, or\n\nnative thiol\/total thiol ratios between groups. We found significant elevations in NO levels in Wilson disease group before drug treatment,\n\nand the 3-NT levels in the Wilson disease groups prior to (P &lt; .05) and under drug treatment (P &lt; .01), when compared to controls.\n\nConclusion: Our data are the first to show that nitrosative stress and thiol\/disulfide homeostasis can contribute to the pathogenesis of\n\nWilson disease.<\/jats:p>","DOI":"10.5152\/tjg.2021.20549","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T03:58:01Z","timestamp":1632283081000},"page":"765-773","source":"Crossref","is-referenced-by-count":5,"title":["Investigation of Dynamic Thiol\/Disulfide Homeostasis and Nitrosative Stress in Patients with Wilson Disease"],"prefix":"10.5152","volume":"32","author":[{"given":"Emine Melis","family":"Y\u00fccel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bugra Tolga","family":"Konduk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Saracaloglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sezgin","family":"Barut\u00e7u","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seniz","family":"Demiry\u00fcrek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Kaba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belma Dogan","family":"G\u00fcngen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah Tuncay","family":"Demiry\u00fcrek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2021,9,15]]},"container-title":["Turkish Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/download\/3775\/3438","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T11:24:43Z","timestamp":1773228283000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/view\/3775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,15]]},"references-count":0,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,9,15]]}},"URL":"https:\/\/doi.org\/10.5152\/tjg.2021.20549","relation":{},"ISSN":["2148-5607"],"issn-type":[{"value":"2148-5607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,15]]}}}