{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T10:25:49Z","timestamp":1788690349571,"version":"build-2803163510"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Gastroenterology"],"abstract":"<jats:p>Background: To identify risk factors for hypovitaminosis D in inflammatory bowel disease and conduct a comprehensive systematic\n\nreview with meta-analysis to quantify the impact on vitamin D deficiency.\n\nMethods: We conducted a literature search of studies through PubMed, Embase, Cochrane Library, and Web of Science. In addition,\n\nrelevant articles were searched manually. Studies were included if the odds ratios (OR) and 95% CI of each risk factor were reported or\n\ncould be calculated. We will use the fixed-effects or random-effects model to estimate the pooled effect.\n\nResults: Out of 1018 articles, 25 eligible studies were identified, including 5826 participants. The risk factors associated with hypovitaminosis\n\nD were non-Caucasian (OR: 3.79, 95% CI: 2.68-5.34), Crohn\u2019s disease (OR: 1.38, 95% CI: 1.21-1.56), disease activity (OR: 1.85,\n\n95% CI: 1.61-2.13), inflammatory bowel disease-related surgery (OR: 1.61, 95% CI: 1.38-1.89), exposure to steroid (OR: 1.61, 95% CI:\n\n1.28-2.03), and biologics (OR: 1.78, 95% CI: 1.48-2.14). In 30 ng\/mL and adjusted OR subgroup, male (OR: 1.84, 95% CI: 1.47-2.31) and\n\nwinter season (OR: 2.49, 95% CI: 1.69-3.67) also were risk factors, respectively. 5-aminosalicylic acid (OR: 1.10, 95% CI: 0.74-1.63) and\n\nsmoking (OR: 1.19, 95% CI: 0.98-1.45) were unrelated to vitamin D deficiency.\n\nConclusions: For vitamin D deficiency in inflammatory bowel disease, non-Caucasian, Crohn\u2019s disease, disease activity, surgery, exposure\n\nto steroid and biologics, males are risk factors, while 5-aminosalicylic acid and smoking are not. The relationship between body\n\nmass index, winter season, exposure to immunomodulators, and vitamin D deficiency remains unclear.<\/jats:p>","DOI":"10.5152\/tjg.2021.20614","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T09:14:13Z","timestamp":1628846053000},"page":"508-518","source":"Crossref","is-referenced-by-count":12,"title":["Risk Factors for Vitamin D Deficiency in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis"],"prefix":"10.5152","volume":"32","author":[{"given":"Shanzhen","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixiang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaxiu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2021,6,15]]},"container-title":["Turkish Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/download\/3742\/3405","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T11:22:15Z","timestamp":1773228135000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/view\/3742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,15]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,6,15]]}},"URL":"https:\/\/doi.org\/10.5152\/tjg.2021.20614","relation":{},"ISSN":["2148-5607"],"issn-type":[{"value":"2148-5607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,15]]}}}