{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:42:07Z","timestamp":1782258127278,"version":"3.54.5"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Gastroenterology"],"abstract":"<jats:p>Background: The pathogenesis of extraesophageal symptoms of gastroesophageal reflux disease is complex, and esophageal motility\n\nand reflux may be involved in it. In this study, we aimed to compare esophageal motility and reflux characteristics in gastroesophageal reflux disease patients with and without extraesophageal symptoms by high-resolution manometry and multichannel intraluminal\n\nimpedance-pH monitoring.\n\nMethods: We retrospectively studied gastroesophageal reflux disease patients between January 2014 and December 2018. All patients\n\nhad undergone high-resolution manometry and multichannel intraluminal impedance-pH monitoring. The results were compared and\n\nanalyzed.\n\nResults: A total of 59 patients were included in this study. Patients were divided into 3 groups according to their main complaint: only\n\ntypical symptoms (group A, n = 11), both typical and extraesophageal symptoms (group B, n = 33), and only extraesophageal symptoms (group C, n = 15). Compared with group A, the lower esophageal sphincter basal pressure, integrated residual pressure, and lower\n\nesophageal sphincter length were lower, and the proximal reflux percentages of a weak acid and non-acid reflux were higher in group B\n\nand group C (P &lt; .017). The positive rate of esophageal motility disorders was lower in group A than in other groups (P &lt; .05). The proportion of patients with multiple rapid swallows\/single swallow\u2014distal contractile integral ratio greater than 1\u2014was higher in group A than\n\nin other groups (P &lt; .05).\n\nConclusions: Decreased lower esophageal sphincter pressure and lower esophageal sphincter length, increased proximal esophageal\n\nreflux of weak acid and non-acid reflux, esophageal motility disorders, and decreased peristaltic reserve are involved in the pathogenesis\n\nof extraesophageal symptoms of gastroesophageal reflux disease<\/jats:p>","DOI":"10.5152\/tjg.2022.201040","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T07:22:10Z","timestamp":1645428130000},"page":"280-285","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of Esophageal Motility and Reflux Characteristics in Patients with Gastroesophageal Reflux Disease With or Without Extraesophageal Symptoms"],"prefix":"10.5152","volume":"33","author":[{"given":"Guoping","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqun","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peifen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2022,4,15]]},"container-title":["Turkish Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/download\/3859\/3521","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T02:30:38Z","timestamp":1771381838000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/view\/3859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,15]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4,15]]}},"URL":"https:\/\/doi.org\/10.5152\/tjg.2022.201040","relation":{},"ISSN":["2148-5607"],"issn-type":[{"value":"2148-5607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,15]]}}}