{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T04:02:29Z","timestamp":1771300949600,"version":"3.50.1"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Gastroenterology"],"abstract":"<jats:p>Background: Hepatitis C is one of the leading causes of death in patients with inherited bleeding disorders. Currently, direct-acting antiviral drugs used for the treatment of hepatitis C have become an effective and a reliable option for people with inherited bleeding disorders. The aim of this study is to report the efficacy and safety of ombitasvir + paritaprevir\/ritonavir and dasabuvir combination in the treatment of hepatitis C in patients with inherited bleeding disorders. Methods: In this retrospective study, we evaluated the efficacy and safety of the combination of ombitasvir + paritaprevir\/ritonavir and dasabuvir in 10 adult patients with hemophilia A, 4 patients with hemophilia B, and 1 patient with von Willebrand disease who were infected with hepatitis C genotype 1. Results: Five patients had genotype 1a and 10 patients had genotype 1b chronic hepatitis C. One patient had Child A cirrhosis, 14 patients had chronic hepatitis C without cirrhosis. Hepatitis C virus ribonucleic acid was negative in all patients at week 4 and at the end of the treatment. Sustained virologic response was obtained in all patients. Serious side effects were detected in 3 patients, which were intra- muscular bleeding, erosive gastritis-related gastrointestinal bleeding, and pneumonia. Conclusion: Ombitasvir + paritaprevir combined with ritonavir and dasabuvir &amp;plusmn; ribavirin is an effective treatment for patients infected with genotype 1 hepatitis C who have coagulation disorders. Tolerance and side effects are similar to other treatment options. Cite this article as: Sonsuz A, Bozcan S, Hatemi \u0130, et al. Efficacy and safety of ombitasvir\/paritaprevir\/ritonavir + dasabuvir &amp;plusmn; ribavirin combinations in patients with genotype 1 hepatitis C and inherited bleeding disorders. Turk J Gastroenterol. 2022;33(5):414-420.<\/jats:p>","DOI":"10.5152\/tjg.2022.20844","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T04:49:47Z","timestamp":1653540587000},"page":"414-420","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and Safety of Ombitasvir\/Paritaprevir\/ Ritonavir + Dasabuvir \u00b1 Ribavirin Combinations in Patients with Genotype 1 Hepatitis C and Inherited Bleeding Disorders"],"prefix":"10.5152","volume":"33","author":[{"given":"Abdullah","family":"Sonsuz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selma","family":"Bozcan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130brahim","family":"Hatemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebati","family":"\u00d6zdemir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Billur","family":"Canbakan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00fcleyman","family":"Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130lkay","family":"G\u00fclt\u00fcrk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cem","family":"Ar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2022,5,15]]},"container-title":["Turkish Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"http:\/\/turkjgastroenterol.org\/index.php\/tjg\/article\/download\/3876\/3538","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T03:09:46Z","timestamp":1771297786000},"score":1,"resource":{"primary":{"URL":"http:\/\/turkjgastroenterol.org\/index.php\/tjg\/article\/view\/3876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,15]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5,15]]}},"URL":"https:\/\/doi.org\/10.5152\/tjg.2022.20844","relation":{},"ISSN":["2148-5607"],"issn-type":[{"value":"2148-5607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,15]]}}}