{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:14:33Z","timestamp":1780319673149,"version":"3.54.1"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Gastroenterology"],"abstract":"<jats:p>Background: One-third of all extraintestinal manifestations are mucocutaneous findings in patients with Crohn&amp;rsquo;s disease and there is a relationship between some risk factors. Our aim is to evaluate factors associated with mucocutaneous manifestations in our cohort of patients with Crohn&amp;rsquo;s disease with a follow-up duration of up to 25 years. Methods: In the study, 336 patients with Crohn&amp;rsquo;s disease who were followed up between March 1986 and October 2011 were included. The demographic characteristics, Crohn&amp;rsquo;s disease-related data, and accompanying mucocutaneous manifestations were recorded. The cumulative probability of mucocutaneous extraintestinal manifestations and possible risk factors were analyzed. Results: Oral and skin involvement were detected in 109 (32%) and 31 (9.2%) patients, respectively. The cumulative probability of developing oral and skin manifestations were 43.2% and 20.3%, respectively. Cox regression analysis showed that female gender (odds ratio: 3.28, 95% CI: 1.51-7.14, P = .003) and corticosteroid use (odds ratio: 7.88, 95% CI: 1.07-57.97, P = .043) are independently associated with the development of skin manifestations, while family history (odds ratio: 3.59, 95% CI: 2.18-5.93, P &amp;lt; .001) and inflammatory-type disease (odds ratio: 1.776, 95% CI: 1.21-2.61, P = .004) were independently associated with the development of oral ulcers. Conclusion: Mucocutaneous extraintestinal manifestations are associated with female gender, corticosteroid use, family history, and disease type in a large cohort of patients with Crohn&amp;rsquo;s disease. Defining the specific relationships of immune-mediated diseases will help to better understand the pathogenesis of Crohn&amp;rsquo;s disease and associated mucocutaneous manifestations and to use more effective treatments. Cite this article as: Kayar Y, Dertli R, Kon&amp;uuml;r S, et al. Mucocutaneous manifestations and associated factors in patients with Crohn&amp;rsquo;s disease. Turk J Gastroenterol. 2022;33(11):945-954.<\/jats:p>","DOI":"10.5152\/tjg.2022.21750","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T09:47:21Z","timestamp":1662976041000},"page":"945-954","source":"Crossref","is-referenced-by-count":2,"title":["Mucocutaneous Manifestations and Associated Factors in  Patients with Crohn\u2019s Disease"],"prefix":"10.5152","volume":"33","author":[{"given":"Yusuf","family":"Kayar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramazan","family":"Dertli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eevki","family":"Kon\u00fcr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"A\u011f\u0131n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Al Kafee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00fclent","family":"Baran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asl\u0131","family":"\u00c7ift\u00e7iba\u015f\u0131 \u00d6rmeci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filiz","family":"Aky\u00fcz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadir","family":"Demir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Be\u015f\u0131\u015f\u0131k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabahattin","family":"Kaymako\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2022,11,15]]},"container-title":["Turkish Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"http:\/\/turkjgastroenterol.org\/index.php\/tjg\/article\/download\/3944\/3606","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T02:59:22Z","timestamp":1771297162000},"score":1,"resource":{"primary":{"URL":"http:\/\/turkjgastroenterol.org\/index.php\/tjg\/article\/view\/3944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,15]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11,15]]}},"URL":"https:\/\/doi.org\/10.5152\/tjg.2022.21750","relation":{},"ISSN":["2148-5607"],"issn-type":[{"value":"2148-5607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,15]]}}}