{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T21:50:59Z","timestamp":1780523459361,"version":"3.54.1"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Gastroenterology"],"abstract":"<jats:p>Background: To determine the effect of intramuscular administration of Neostigmine&amp;reg; on the visualization of the pancreatic duct on magnetic resonance cholangiopancreatography in patients with recurrent acute pancreatitis or abdominal pain. Methods: We reviewed patients undergoing magnetic resonance cholangiopancreatography followed by a Neostigmine&amp;reg;-enhanced magnetic resonance cholangiopancreatography. Patients with a history of recurrent acute pancreatitis or abdominal pain who had a magnetic resonance cholangiopancreatography where the pancreatic duct was not entirely seen, were selected to undergo a second magnetic resonance cholangiopancreatography 40 minutes after 0.5 mg Neostigmine&amp;reg;. Images were analyzed by 2 radiologists. The diameter of the pancreatic duct was measured in the head, body, and tail of the pancreas on the baseline images and after Neostigmine&amp;reg;. Results: Ten patients were included, with a median age of 33 years (range 15-61). The maximum diameter of the pancreatic duct increased significantly after Neostigmine&amp;reg; administration in all patients, from 1.84 &amp;plusmn; 0.98 to 3.41 &amp;plusmn; 1.27 mm in the head, 1.34 &amp;plusmn; 0.42 mm to 2.5 &amp;plusmn; 0.49 mm in the body and 0.72 &amp;plusmn; 0.52 mm to 1.78 &amp;plusmn; 0.43 mm in the tail (mean &amp;plusmn; SD, P &amp;lt; .0001). Neostigmine&amp;reg; helped to provide better detail of the pancreatic duct anatomy in 4 patients. In 2 patients we confirmed pancreas divisum, in another the Santorini duct was not seen on the baseline images but it was clearly visualized after Neostigmine&amp;reg;, and in the fourth patient, Neostigmine&amp;reg; improved visualization of multiple pancreatic duct stenosis. Conclusion: Neostigmine&amp;reg;-magnetic resonance cholangiopancreatography significantly increases the diameter of the pancreatic duct, allowing an accurate morphological evaluation. It could be a cheap alternative to secretin, which is expensive and hardly available. Cite this article as: Toledo PF, C&amp;aacute;rdenas G, Berger Z, Simian D, Araya F. Neostigmine&amp;reg; improves pancreatic duct visualization in magnetic resonance cholangiopancreatography and could be a cheap alternative for secretin. Turk J Gastroenterol. 2022;33(8):704-709.<\/jats:p>","DOI":"10.5152\/tjg.2022.21864","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T04:44:45Z","timestamp":1658205885000},"page":"704-709","source":"Crossref","is-referenced-by-count":1,"title":["Neostigmine\u00ae Improves Pancreatic Duct Visualization in Magnetic Resonance Cholangiopancreatography and Could Be a Cheap Alternative for Secretin"],"prefix":"10.5152","volume":"33","author":[{"given":"Paulina F.","family":"Toledo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"C\u00e1rdenas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Simian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Araya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2022,8,15]]},"container-title":["Turkish Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"http:\/\/turkjgastroenterol.org\/index.php\/tjg\/article\/download\/3913\/3575","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T03:04:12Z","timestamp":1771297452000},"score":1,"resource":{"primary":{"URL":"http:\/\/turkjgastroenterol.org\/index.php\/tjg\/article\/view\/3913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,15]]},"references-count":0,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,8,15]]}},"URL":"https:\/\/doi.org\/10.5152\/tjg.2022.21864","relation":{},"ISSN":["2148-5607"],"issn-type":[{"value":"2148-5607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,15]]}}}