{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:07:16Z","timestamp":1783426036444,"version":"3.54.6"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Gastroenterology"],"abstract":"<jats:p>Background: The number of cases of irritable bowel syndrome is growing worldwide, in which adenomatous polyps can develop as a result of microinflammation of the colonic epithelium. Our study was aimed at the identification of the possible effect of single-nucleotide polymorphisms on the risk of the development of irritable bowel syndrome-related colonic adenomatous polyps. Materials and Methods: The study involved 187 irritable bowel syndrome patients. The single-nucleotide polymorphisms were investigated by the polymerase chain reaction method and DNA was extracted with the phenol-chloroform: interleukin-1&amp;beta; gene-31C\/T (rs1143627), -511C\/T (rs16944); interleukin-6 gene-174G\/C (rs1800795); interleukin-10 gene-592C\/A (rs1800872), -819T\/C (rs1800871), -1082A\/G (rs1800896); Toll-like receptor-2 gene Arg753Gln (rs5743708); Toll-like receptor-4 gene Thr399ile (rs4986791), Asp299Gly (rs4986790); and metalloproteinase-9 gene-8202A\/G (rs11697325). The study of polymorphic loci was checked for compliance with the Hardy&amp;ndash; Weinberg equilibrium using Fisher&amp;rsquo;s exact test along with the analyses of the frequency of alleles and the genotypes. Results: The association of diseases with G allele Toll-like receptor-2 gene Arg753Gln (rs5743708) was revealed in irritable bowel syndrome patients with adenomatous polyps of the colon (P &amp;lt; .0006) and AG single-nucleotide polymorphisms s of Toll-like receptor-2 gene (&amp;chi;2 = 12.78, P &amp;lt; .002); A allele had a protective effect. The AG genotype metalloproteinase-9 gene-8202A\/G (rs11697325) polymorphism in irritable bowel syndrome patients with adenomatous polyps of the colon had a protective effect (P &amp;lt; .05). AA genotype interleukin-10 gene-1082A\/G (rs1800896) polymorphism in the irritable bowel syndrome patient (&amp;chi;2 = 33.97, 4.0E-8) can be considered as the risk for adenomatous polyps of the colon in irritable bowel syndrome. Conclusion: G allele Toll-like receptor-2 gene Arg753Gln (rs5743708) and AA genotype interleukin-10 gene-1082A\/G (rs1800896) polymorphisms can be the marker of the emergence of adenomatous polyps of the colon concomitant with irritable bowel syndrome. Cite this article as: Kyrian O, Dorofeyev A, Derkach I, Zhigal Y. Evaluation of the impact of some single-nucleotide gene polymorphisms on the development of adenomatous polyps of the colon in patients with irritable bowel syndrome. Turk J Gastroenterol. 2023;34(8):822-830.<\/jats:p>","DOI":"10.5152\/tjg.2023.21985","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T09:16:30Z","timestamp":1688548590000},"page":"822-830","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of the Impact of Some Single-Nucleotide Gene Polymorphisms on the Development of Adenomatous Polyps of the Colon in Patients with Irritable Bowel Syndrome"],"prefix":"10.5152","volume":"34","author":[{"given":"Olena","family":"Kyrian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Dorofeyev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Derkach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia","family":"Zhigal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2023,8,15]]},"container-title":["Turkish Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"http:\/\/turkjgastroenterol.org\/index.php\/tjg\/article\/download\/4016\/3678","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T02:50:20Z","timestamp":1771296620000},"score":1,"resource":{"primary":{"URL":"http:\/\/turkjgastroenterol.org\/index.php\/tjg\/article\/view\/4016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,15]]},"references-count":0,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,8,15]]}},"URL":"https:\/\/doi.org\/10.5152\/tjg.2023.21985","relation":{},"ISSN":["2148-5607"],"issn-type":[{"value":"2148-5607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,15]]}}}