{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:36:28Z","timestamp":1780554988423,"version":"3.54.1"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"2","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Gastroenterology"],"abstract":"<jats:p>Background\/Aims: Crohn&amp;rsquo;s disease (CD) is a major subtype of chronic relapsing inflammatory gastrointestinal disorders. In this study, we assessed the possible contributions of serum oxidative\/nitrosative stress and dynamic thiol\/disulfide homeostasis to CD pathogenesis.\nMaterials and Methods: Patients with active CD (A-CD) at onset (n = 38), CD patients in the remission (R-CD) (n = 38), and healthy controls (n = 38) were prospectively included in this study. Serum oxidative\/nitrosative parameters as well as total thiol and native thiol levels were analyzed.\nResults: We observed significant augmentation in nitric oxide (NO) levels in both A-CD and R-CD patients compared to healthy controls. We detected marked reductions in the 3-nitrotyrosine levels in the patient groups. Glutathione, glutathione peroxidase, and myeloperoxidase levels were observed to be significantly lower in both the active and remission groups (P &amp;lt; .001). In the A-CD group, native thiol (P &amp;lt; .001) and total thiol (P &amp;lt; .01) levels were lower, and disulfide levels were higher than those of the control group (P &amp;lt; .01), while the native thiol\/total thiol ratio was reduced and disulfide\/total thiol (P &amp;lt; .001) and disulfide\/native thiol (P &amp;lt; .001) ratios were elevated. Remarkably, no change in dynamic thiol\/disulfide homeostasis was found in the R-CD group.\nConclusion: Our results showed increased serum NO levels and decreased antioxidant enzymes, particularly during the active phase of CD. Determination of thiol\/disulfide homeostasis could help differentiate between the active and remission phases of the disease. Thiol\/ disulfide parameters can be used as biomarkers for A-CD.\nCite this article as: Aysun Ba\u011fda\u015f A, Barut&amp;ccedil;u S, Saracalo\u011flu A, Demiry&amp;uuml;rek AT. Assessment of serum dynamic thiol\/disulfide homeostasis and oxidative\/nitrosative stress in patients with Crohn&amp;rsquo;s disease. Turk J Gastroenterol. 2025;36(2):114-123.<\/jats:p>","DOI":"10.5152\/tjg.2024.23519","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T06:43:48Z","timestamp":1732689828000},"page":"114-123","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of Serum Dynamic Thiol\/Disulfide Homeostasis and Oxidative\/Nitrosative Stress in Patients with Crohn\u2019s Disease"],"prefix":"10.5152","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1618-4644","authenticated-orcid":false,"given":"Ancel","family":"Aysun Ba\u011fda\u015f","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0823-3215","authenticated-orcid":false,"given":"Sezgin","family":"Barut\u00e7u","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2534-6051","authenticated-orcid":false,"given":"Ahmet","family":"Saracalo\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9994-8541","authenticated-orcid":false,"given":"Abdullah Tuncay","family":"Demiry\u00fcrek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2025,12,18]]},"container-title":["Turkish Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/download\/4197\/3859","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T13:55:57Z","timestamp":1766584557000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/view\/4197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,18]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,1,31]]}},"URL":"https:\/\/doi.org\/10.5152\/tjg.2024.23519","relation":{},"ISSN":["2148-5607"],"issn-type":[{"value":"2148-5607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,18]]}}}