{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:17:23Z","timestamp":1784762243723,"version":"3.55.0"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"6","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Gastroenterology"],"abstract":"<jats:p>Background\/Aims: Elevated intra-abdominal pressure (IAP) can lead to intra-abdominal\u00a0 hypertension (IAH) and, in severe cases, abdominal compartment syndrome (ACS) in patients with cirrhosis and ascites. Paracentesis reduces IAP and improves abdominal perfusion. Intra-abdominal hypertension can also trigger acute-on-chronic liver failure (ACLF) in decompensated cirrhosis. This study evaluates the association between IAH and short-term mortality in patients with cirrhosis and ascites.\nMaterials and Methods: This prospective, single-center cohort study included 18 patients (7 females, 11 males; median age: 59) sched uled for therapeutic paracentesis. Intra-abdominal pressure was measured using the bladder technique. Patients were grouped based on initial Chronic Liver Failure Consortium Organ Failure (CLIF-C OF) scores as ACLF or non-ACLF and followed up for 3 months.\nResults: The median model for end-stage liver disease score was 17 (IQR 11-19). The primary etiologies of cirrhosis were viral hepatitis and alcoholic liver disease. Independent risk factors for IAH included advanced liver disease and large-volume ascites. Pre paracentesis IAP was higher in ACLF patients (22 vs. 18 mm Hg). Post-paracentesis IAP was also higher in ACLF patients (14 vs. 8 mm Hg, P = .007). The 3-month mortality rate was 50%, with worse survival in ACLF patients (24 vs. 76.9 days, P = .002). Pre-paracentesis\u00a0 IAP was signifi cantly higher in patients who died (22 vs. 18 mm Hg, P = .034), and survival was worse in those with IAP #18.5 mm Hg (P = .026).\nConclusion: Intra-abdominal pressure is elevated in cirrhosis patients with grade 3 ascites. Despite similar paracentesis volumes, IAP remained higher in the ACLF group. Intra-abdominal pressure #18.5 mm Hg is associated with significantly reduced survival, indicating that IAH accelerates short-term mortality in these patients.\n\u00a0\nCite this article as: Mutlu U, Genc Ulucecen S, Iliaz R, et al. Intra-abdominal hypertension and its prognostic impact on mortality in cirrhotic patients with ascites: The role of paracentesis. Turk J Gastroenterol. 2025;36(6):390-397.<\/jats:p>","DOI":"10.5152\/tjg.2025.24375","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T09:57:08Z","timestamp":1748944628000},"page":"390-397","source":"Crossref","is-referenced-by-count":5,"title":["Intra-Abdominal Hypertension and Its Prognostic Impact  on Mortality in Cirrhotic Patients with Ascites: The Role of  Paracentesis"],"prefix":"10.5152","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5259-7326","authenticated-orcid":false,"given":"Ummu","family":"Mutlu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7552-3816","authenticated-orcid":false,"given":"Sezen Genc","family":"Ulucecen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3635-1967","authenticated-orcid":false,"given":"Raim","family":"Iliaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1791-897X","authenticated-orcid":false,"given":"Alp","family":"Atasoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2203-4255","authenticated-orcid":false,"given":"Bilger","family":"Cavus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6297-8045","authenticated-orcid":false,"given":"Asli Ciftcibasi","family":"Ormeci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7498-141X","authenticated-orcid":false,"given":"Filiz","family":"Akyuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5226-3705","authenticated-orcid":false,"given":"Kadir","family":"Demir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4910-249X","authenticated-orcid":false,"given":"Sabahattin","family":"Kaymakoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5184-376X","authenticated-orcid":false,"given":"Fatih","family":"Besisik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2025,1,13]]},"container-title":["Turkish Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/turkjgastroenterol.org\/index.php\/tjg\/article\/download\/4233\/3896","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/turkjgastroenterol.org\/index.php\/tjg\/article\/download\/4233\/3896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:29:08Z","timestamp":1767666548000},"score":1,"resource":{"primary":{"URL":"https:\/\/turkjgastroenterol.org\/index.php\/tjg\/article\/view\/4233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,13]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6,2]]}},"URL":"https:\/\/doi.org\/10.5152\/tjg.2025.24375","relation":{},"ISSN":["2148-5607"],"issn-type":[{"value":"2148-5607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,13]]}}}