{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:20:46Z","timestamp":1789172446154,"version":"build-2803163510"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"10","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Gastroenterology"],"abstract":"<jats:p>Background\/Aims: The study focuses on examining the impact of Helicobacter pylori (H. pylori) on the modulation of the miRNA expres sion profiles while also unraveling the associated pathways that play a significant role in initiating and driving the development of gastric cancer (GC).\nMaterials and Methods: An in-depth analysis of miRNA expression profiles in gastric tissue samples from patients with chronic superficial gastritis (CSG), chronic atrophic gastritis (CAG), dysplasia (Dys), or GC was conducted. The carbon-13 urea breath test was used to identify H. pylori infection, and the participant cohort was characterized by the presence of H. pylori infection. Additionally, the role of miR-196a\/b-5p in GC carcinogenesis was investigated.\nResults: A total of five miRNAs\u2014miR-196a-5p, 196b-5p, 224-5p, 424-3p, and 941\u2014demonstrated marked elevation in CSG, CAG, Dys, and GC. miR-196a\/b-5p was observed to be upregulated in GC cells following H. pylori infection, as well as in Dys and GC tissue samples from patients harboring H. pylori. miR-196a\/b-5p can expedite GC progression. Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1), the target gene of miR-196a\/b-5p, diminishes the proliferation capability of GC cells; however, miR-196a\/b-5p can partially counteract this effect. miR-196a\/b-5p activates the PI3K-Akt pathway, while IGF2BP1 inhibits the expression of these proteins.\nConclusion: The levels of miR-196a\/b-5p were observed to escalate following H. pylori infection, subsequently fostering the progression of GC by specifically targeting IGF2BP1 and triggering the PI3K-Akt signaling cascade.\n\u00a0\nCite this article as: Chen K, Chen JW, Shen Y, et al. Helicobacter pylori promoted miR 196a\/b-5p expression and accelerated tumorigenesis of the gastric mucosa by targeting IGF2BP1 and activating PI3K-Akt signaling pathway. Turk J Gastroenterol. 2025;36(10):658-668.<\/jats:p>","DOI":"10.5152\/tjg.2025.24397","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T02:19:37Z","timestamp":1746757177000},"page":"658-668","source":"Crossref","is-referenced-by-count":1,"title":["Helicobacter pylori Promoted miR-196a\/b-5p Expression  and Accelerated Tumorigenesis of the Gastric Mucosa by  Targeting IGF2BP1 and Activating PI3K-Akt Signaling  Pathway"],"prefix":"10.5152","volume":"36","author":[{"given":"Ke","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Rong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Xue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Juan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Min","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Nan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Ying","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Le","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Mei","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2025,5,5]]},"container-title":["Turkish Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/turkjgastroenterol.org\/index.php\/tjg\/article\/download\/4268\/3929","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/turkjgastroenterol.org\/index.php\/tjg\/article\/download\/4268\/3929","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:35:07Z","timestamp":1787837707000},"score":1,"resource":{"primary":{"URL":"https:\/\/turkjgastroenterol.org\/index.php\/tjg\/article\/view\/4268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,5]]},"references-count":0,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10,15]]}},"URL":"https:\/\/doi.org\/10.5152\/tjg.2025.24397","relation":{},"ISSN":["2148-5607"],"issn-type":[{"value":"2148-5607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,5]]}}}