{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T00:13:14Z","timestamp":1794269594067,"version":"4.9.0"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"9","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Gastroenterology"],"abstract":"<jats:p>Background\/Aims: Distinct virological relapse (VR) has occurred after stopping the use of nucleos(t)ide analogues treatment in patients with chronic hepatitis B (CHB) who are positive for Hepatitis B e antigen (HBeAg). Here, we aimed to identify serum miR-146a and miR- 155 in HBeAg-positive patients with CHB and their relationship with VR after entecavir (ETV) discontinuance.\r\nMaterials and Methods: Ninety-eight patients with CHB and positive for HBeAg before initiating treatment were analyzed. Virological relapse was defined as 2 consecutive examinations (3 months apart) after treatment discontinuance, both showing an HBV DNA load of more than &gt;2000 IU\/mL.\r\nResults: Compared to control, CHB patients were observed with increases in serum miR-146a and miR-155 before starting ETV treatment (P &lt; .001). There were 52 patients (53.1%) experiencing VR at 12 months after discontinuance of ETV treatment. The VR group was demonstrated with increases in serum miR-146a and miR-155 than the non-VR group before starting ETV treatment (P &lt; .001). Whether at the beginning of ETV discontinuance or at 12 months after ETV discontinuance, the VR group was noted with elevations in serum miR-146a and miR-155 than the non-VR group (P &lt; .001).\r\nConclusion: The findings demonstrated that miR-146a and miR-155 levels in the circulation may be promising assessment tools for identifying sustained-virological responders after ETV discontinuance in CHB patients.\r\n\u00a0\r\nCite this article as: Xu ML, Wang LH. Serum miR-146a and miR-155 as predictors of virological control after entecavir withdrawal in HBeAg-positive chronic hepatitis B Patients. Turk J Gastroenterol. 2025;36(9):583-589.<\/jats:p>","DOI":"10.5152\/tjg.2025.24685","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T12:53:44Z","timestamp":1756299224000},"page":"583-589","source":"Crossref","is-referenced-by-count":1,"title":["Serum miR-146a and miR-155 as Predictors of Virological Control After Entecavir Withdrawal in HBeAg-Positive Chronic Hepatitis B Patients"],"prefix":"10.5152","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8755-2367","authenticated-orcid":false,"given":"Ming Li","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9784-6050","authenticated-orcid":false,"given":"Li Huan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2025,3,18]]},"container-title":["Turkish Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/turkjgastroenterol.org\/index.php\/tjg\/article\/download\/4282\/3941","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/turkjgastroenterol.org\/index.php\/tjg\/article\/download\/4282\/3941","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:37:43Z","timestamp":1787837863000},"score":1,"resource":{"primary":{"URL":"https:\/\/turkjgastroenterol.org\/index.php\/tjg\/article\/view\/4282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,18]]},"references-count":0,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9,15]]}},"URL":"https:\/\/doi.org\/10.5152\/tjg.2025.24685","relation":{},"ISSN":["2148-5607"],"issn-type":[{"value":"2148-5607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,18]]}}}