{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T13:59:18Z","timestamp":1766584758250,"version":"3.48.0"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Gastroenterology"],"abstract":"<jats:p>Background\/Aims: Selecting the initial antiviral regimen for chronic hepatitis B (CHB) requires balancing patients\u2019 comorbidities and long-term safety. This study examines differences in patient and disease-related factors that guide clinicians to prescribe either ente cavir (ETV) or tenofovir disoproxil fumarate (TDF) as the initial treatment.\r\nMaterials and Methods: The study included treatment-na\u00efve CHB patients aged 18 or older who had been diagnosed for at least 1 year since 2010 and initiated on antiviral therapy. The data included variables such as age, gender, body mass index (BMI), comorbidities, liver disease activity, biopsy results, cirrhosis, hepatic steatosis, hepatitis B e-antigen status, hepatitis B virus DNA levels, triglycerides, cholesterol, renal function, and baseline bone mineral density (BMD), which were assessed by dual-energy x-ray absorptiometry (DEXA).\r\nResults: Among 2259 patients (61.6% male), 1270 patients (56.22%) received TDF, while 989 patients (43.78%) received ETV as firstline therapy. The TDF was more commonly prescribed to patients with a lower BMI (median<\/jats:p>","DOI":"10.5152\/tjg.2025.24741","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T16:19:55Z","timestamp":1761322795000},"source":"Crossref","is-referenced-by-count":0,"title":["A National Multicenter Study on Initial Antiviral Treatment  Preferences on Chronic Hepatitis B: Entecavir Versus  Tenofovir Disoproxil 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