{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T13:59:27Z","timestamp":1766584767048,"version":"3.48.0"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Gastroenterology"],"abstract":"<jats:p>Background\/Aims: To assess the correlation between indocyanine green retention rate at 15 minutes (ICG-R15), liver stiffness mea surement (LSM), and other clinical indicators in cirrhotic patients, using hepatic venous pressure gradient (HVPG) as a reference and to evaluate the predictive capability of ICG-R15 for clinically significant portal hypertension (CSPH).\nMaterials and Methods: From February 2023 to September 2024, 80 cirrhotic patients were recruited. Data collected included baseline information, laboratory results, HVPG measurements, and ICG-R15 via the ICG clearance test. Patients were classified into non-CSPH (n = 33) and CSPH (n = 47) groups based on HVPG. Pearson\u2019s correlation analyzed relationships between HVPG, ICG-R15, LSM, and other indicators. Logistic regression was used to identify risk factors for CSPH and develop a predictive model, evaluated by receiver operating characteristic curve.\nResults: The CSPH patients showed lower white blood cell count, red blood cell count, hemoglobin, platelet count (PLT), and albumin, with higher total bilirubin (TBil), prothrombin time, LSM, and ICG-R15. Significant correlations were found between HVPG and ICG-R15 (r = 0.662) and LSM (r = 0.633) (both P &lt; .001). The ICG-R15, LSM, PLT, and TBil were independent risk factors for CSPH. The model had an AUC of 0.947, sensitivity of 78.72%, and specificity of 96.97%.\nConclusion: The ICG-R15 is a significant predictor of CSPH, and a model incorporating ICG-R15 can effectively assess disease severity and predict prognosis in cirrhotic patients.\n\u00a0\nCite this article as: Hu H, Lai W, Zhou T, Zhu J, Yan H. Indocyanine green retention rate at 15 minutes as a key predictor of clinically significant portal hypertension in cirrhosis: development and validation of a superior non-invasive diagnostic model. Turk J Gastroenterol. Published online October 10, 2025. doi:10.5152\/tjg.2025.25155.<\/jats:p>","DOI":"10.5152\/tjg.2025.25155","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T06:02:21Z","timestamp":1760421741000},"source":"Crossref","is-referenced-by-count":0,"title":["Indocyanine Green Retention Rate at 15 Minutes as a Key  Predictor of Clinically Significant Portal Hypertension  in Cirrhosis: Development and Validation of a Superior  Non-Invasive Diagnostic Model"],"prefix":"10.5152","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7730-1554","authenticated-orcid":false,"given":"Han","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6003-1827","authenticated-orcid":false,"given":"Wei","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4383-199X","authenticated-orcid":false,"given":"Tiantian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0383-2684","authenticated-orcid":false,"given":"Jie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2792-7490","authenticated-orcid":false,"given":"Huadong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2025,10,10]]},"container-title":["Turkish Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/download\/4351\/4015","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/download\/4351\/4015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T13:56:40Z","timestamp":1766584600000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/view\/4351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,10]]},"references-count":0,"URL":"https:\/\/doi.org\/10.5152\/tjg.2025.25155","relation":{},"ISSN":["2148-5607"],"issn-type":[{"type":"electronic","value":"2148-5607"}],"subject":[],"published":{"date-parts":[[2025,10,10]]}}}