{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T17:17:12Z","timestamp":1769447832175,"version":"3.49.0"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"1","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Gastroenterology"],"abstract":"<jats:p>Background\/Aims:\u00a0 The\u00a0 prevalence\u00a0 of\u00a0 metabolic\u00a0 dysfunction-associated\u00a0 steatotic\u00a0 liver\u00a0 disease\u00a0 (MASLD)\u00a0 is\u00a0 increasing\u00a0 globally.\u00a0 The\u00a0 Fibrosis-4 (FIB-4) score is a noninvasive biomarker used for assessing potential advanced fibrosis. The study aimed to evaluate the role of the FIB-4 score in predicting postoperative complications and mortality in patients undergoing surgery.\nMaterials and Methods: This multicenter retrospective study included 11 072 patients who underwent surgery under general anesthesia. Demographic and clinical data\u2014including age, gender, comorbidities, FIB-4 scores, American Society of Anesthesiologists classification, postoperative complications, and mortality\u2014were analyzed.\nResults:\u00a0 A\u00a0 total\u00a0 of\u00a0 1667\u00a0 MASLD\u00a0 patients\u00a0 were\u00a0 included.\u00a0 Patients\u00a0 were\u00a0 classified\u00a0 based\u00a0 on\u00a0 FIB-4\u00a0 scores:\u00a0 70%\u00a0 (n\u00a0 =\u00a0 1167)\u00a0 had\u00a0 FIB-4\u00a0 &lt;1.30, 25.1% (n = 418) had 1.30 &lt; FIB-4 \u2264 2.67, and 4.9% (n = 82) had FIB-4 \u2265 2.67. Due to the limited number of patients with possible advanced fibrosis (FIB-4 \u2265 2.67), propensity score (PS) matching was performed. After PS matching, patients with a high FIB-4 score exhibited a significantly higher rate of postoperative complications (P &lt; .001), and 12-month mortality was elevated (11%), although the difference was not statistically significant (P = .481).\nConclusion: A high FIB-4 score may serve as a predictive marker for postoperative complications in patients with MASLD undergoing surgery.\nCite this article as: Eren F, Goktug MR, Ari D, et al. Fibrosis-4 score and postoperative outcomes in metabolic dysfunction-associated steatotic liver disease. Turk J Gastroenterol. 2026;37(1):127-135.<\/jats:p>","DOI":"10.5152\/tjg.2026.25693","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T07:16:20Z","timestamp":1769411780000},"page":"127-135","source":"Crossref","is-referenced-by-count":0,"title":["Fibrosis-4 Score and Postoperative Outcomes in Metabolic  Dysfunction-Associated Steatotic Liver Disease"],"prefix":"10.5152","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2667-8963","authenticated-orcid":false,"given":"Fatih","family":"Eren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6661-1523","authenticated-orcid":false,"given":"Mehmet Refik","family":"Goktug","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8024-781X","authenticated-orcid":false,"given":"Derya","family":"Ari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3459-1868","authenticated-orcid":false,"given":"Gulsah Fidan","family":"Ozkumur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7882-0904","authenticated-orcid":false,"given":"Eda Nur","family":"Bulbuller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5856-5384","authenticated-orcid":false,"given":"Genco","family":"Gencdal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2522-1550","authenticated-orcid":false,"given":"Yuksel","family":"Guleryuzlu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6304-5554","authenticated-orcid":false,"given":"Caglayan","family":"Keklikkiran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6769-9344","authenticated-orcid":false,"given":"Dinc","family":"Dincer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3660-7237","authenticated-orcid":false,"given":"Dilara Turan","family":"Gokce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0203-8075","authenticated-orcid":false,"given":"Askin","family":"Erdogan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4624-2542","authenticated-orcid":false,"given":"Meral","family":"Akdogan Kayhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8222-2384","authenticated-orcid":false,"given":"Mehmet Kursad","family":"Keskin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9518-541X","authenticated-orcid":false,"given":"Selcan","family":"Akesen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1114-6051","authenticated-orcid":false,"given":"Gokhan","family":"Ocakoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3208-6211","authenticated-orcid":false,"given":"Murat","family":"Kiyici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3111","published-online":{"date-parts":[[2026,1,5]]},"container-title":["Turkish Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/download\/4393\/4065","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/download\/4393\/4065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T07:16:21Z","timestamp":1769411781000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/view\/4393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,5]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,5]]}},"URL":"https:\/\/doi.org\/10.5152\/tjg.2026.25693","relation":{},"ISSN":["2148-5607"],"issn-type":[{"value":"2148-5607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,5]]}}}