{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:51:40Z","timestamp":1791359500201,"version":"4.3.1"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Gastroenterology"],"abstract":"<jats:p>Background\/Aims: Minocycline is a semisynthetic tetracycline with potent antimicrobial activity against Helicobacter pylori (H. pylori) and favorable pharmacokinetic properties. Although minocycline-based bismuth quadruple therapy (BQT) has shown encouraging eradication rates in controlled studies, evidence from real-world practice remains limited. This study assessed the effectiveness, safety,\r\nand cost-effectiveness of minocycline-containing BQT in a real-world setting.\r\nMaterials and Methods: In this multicenter, real-world observational study conducted at 25 hospitals in Fujian Province, China, between January and March 2025, adults with confirmed H. pylori infection were treated with 1 of 3 14-day BQT regimens: PBAC (amoxicillin\u2013 clarithromycin), PBMC (minocycline\u2013clarithromycin), or PBML (minocycline levofloxacin), each combined with esomeprazole and bismuth. The primary endpoint was H. pylori eradication confirmed by a 13C-urea breath test after treatment. Secondary endpoints included adverse events, treatment adherence, and cost-effectiveness.\r\nResults: Of the 347 enrolled patients (PBAC, n = 115; PBMC, n = 117; and PBML, n = 115), 330 completed treatment and follow-up and were included in the per-protocol (PP) analysis. In the intention-to-treat analysis, eradication rates were 77.4% (89\/115), 85.5% (100\/117), and 84.3% (97\/115) in the PBAC, PBMC, and PBML groups, respectively (P = .217); corresponding PP eradication rates were 80.9% (89\/110), 90.9% (100\/110), and 88.2% (97\/110) (P = .079). Minocycline-containing regimens achieved numerically higher eradication rates than the amoxicillin-containing regimen. Adverse events occurred in 32.7%, 20.9%, and 23.6% of patients in the PBAC, PBMC, and PBML groups, respectively, while treatment adherence exceeded 94% in all groups. Pharmacoeconomic analysis identified PBML as the most cost-effective regimen (5.38 Chinese Yuan [CNY] per 1% eradication), followed by PBAC (5.41 CNY per 1% eradication) and PBMC (6.06 CNY per 1% eradication).\r\nConclusion: Minocycline-containing BQT demonstrated good tolerability, favorable cost effectiveness, and numerically higher eradication rates in routine clinical practice. It may represent a practical alternative to conventional amoxicillin- or tetracycline-based regimens. Further randomized trials are needed to validate these findings.\r\nCite this article as: Lin H, Chen Q, Cheng X, et al. Minocycline-containing bismuth quadruple therapy for Helicobacter pylori treatment: A multicenter real-world observational study. Turk J Gastroenterol. Published online October 7, 2026. doi: 10.5152\/tjg.2026.26128.<\/jats:p>","DOI":"10.5152\/tjg.2026.26128","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:10:56Z","timestamp":1791357056000},"source":"Crossref","is-referenced-by-count":0,"title":["Minocycline-Containing Bismuth Quadruple Therapy for Helicobacter pylori Treatment: A Multicenter Real-World Observational Study"],"prefix":"10.5152","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4205-1589","authenticated-orcid":false,"given":"Hong","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9388-0147","authenticated-orcid":false,"given":"Qiuzhao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3112-5598","authenticated-orcid":false,"given":"Xianxing","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7631-3924","authenticated-orcid":false,"given":"Huping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4749-0807","authenticated-orcid":false,"given":"Yanling","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3692-5251","authenticated-orcid":false,"given":"Yi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2803-2277","authenticated-orcid":false,"given":"Xueping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2093-7733","authenticated-orcid":false,"given":"Yufan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2026,10,7]]},"container-title":["Turkish Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/download\/4757\/4464","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/download\/4757\/4464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:10:56Z","timestamp":1791357056000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/view\/4757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":0,"URL":"https:\/\/doi.org\/10.5152\/tjg.2026.26128","relation":{},"ISSN":["2148-5607"],"issn-type":[{"value":"2148-5607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]}}}