{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:52:16Z","timestamp":1791273136501,"version":"4.1.0"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Gastroenterology"],"abstract":"<jats:p>Background\/Aims: Monitoring endoscopic inflammation in Crohn\u2019s disease (CD) is difficult. This study examined whether X-C motif chemokine ligand 1 (XCL1) is associated with endoscopic activity, as defined by the Simple Endoscopic Score for Crohn\u2019s Disease (SES-CD).\r\nMaterials and Methods: This was a single-center observational biomarker study. Peripheral blood mononuclear cell (PBMC) transcriptome sequencing was performed in 6 patients with newly diagnosed CD and 6 controls without inflammatory bowel disease. XCL1 protein expression was evaluated using immunohistochemistry and western blotting in 12 intestinal biopsy samples. Serum XCL1 levels were measured using enzyme-linked immunosorbent assay in 125 patients with CD and 40 controls. Patients with CD were classified according to the SES-CD. Correlation, logistic regression, receiver operating characteristic, bootstrap validation, and treatmentadjusted analyses were performed.\r\nResults: XCL1 was upregulated in PBMCs and increased in the intestinal mucosa of patients with active disease. Serum XCL1 levels differed among controls and SES-CD groups (P &lt; .001). In patients with CD, serum XCL1 correlated with SES-CD (r = 0.692), fecal calprotectin (FC) (r = 0.573), Crohn\u2019s Disease Activity Index (r = 0.420), and C-reactive protein (CRP) (r = 0.433; all P &lt; .001). XCL1 remained associated with endoscopic activity after adjustment (odds ratio = 1.005, 95% CI= 1.001-1.008, P = .012). The areas under the curve were 0.76 for XCL1, 0.81 for FC, and 0.85 for the XCL1+FC+CRP model.\r\nConclusion: Although serum XCL1 was associated with SES-CD\u2013defined endoscopic activity, its performance was lower than that of FC. XCL1 may serve as an exploratory adjunctive serum marker but requires further validation.\r\nCite this article as: Li Z, Hao Y, Chen J, Liu X, Xu W, Cheng Y. Serum X-C motif chemokine ligand 1 is associated with endoscopic activity in Crohn\u2019s disease: A clinical biomarker study. Turk J Gastroenterol. Published online October 06, 2026. doi: 10.5152\/tjg.2026.26373.<\/jats:p>","DOI":"10.5152\/tjg.2026.26373","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:12:29Z","timestamp":1791270749000},"source":"Crossref","is-referenced-by-count":0,"title":["Serum X-C Motif Chemokine Ligand 1 Is Associated with Endoscopic Activity in Crohn\u2019s Disease: A Clinical Biomarker Study"],"prefix":"10.5152","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1492-1678","authenticated-orcid":false,"given":"Zhen","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7040-4314","authenticated-orcid":false,"given":"Yuexin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2026,10,6]]},"container-title":["Turkish Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/download\/4752\/4460","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/download\/4752\/4460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:12:29Z","timestamp":1791270749000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/view\/4752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"references-count":0,"URL":"https:\/\/doi.org\/10.5152\/tjg.2026.26373","relation":{},"ISSN":["2148-5607"],"issn-type":[{"value":"2148-5607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,6]]}}}