{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:06:45Z","timestamp":1790766405743,"version":"4.1.0"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turkish Journal of Gastroenterology"],"abstract":"<jats:p>Background\/Aims: Serum amyloid A (SAA) is an acute-phase protein whose sustained elevation is required for AA amyloid fibril formation. Although AA amyloidosis is a rare complication of solid organ transplantation, the long term SAA profile of clinically stable pediatric liver transplant recipients remains unknown. This study aimed to characterize long-term SAA concentrations in this population.\r\nMaterials and Methods: This observational study included 51 pediatric liver transplant recipients and 50 children with acute febrile infections. Cross-sectional SAA measurements were obtained in clinically stable recipients at least 6 months after transplantation. Children with acute febrile infections served as a high-inflammation reference group. In addition, 7 recipients underwent serial SAA measurements before transplantation and at 1 week, 1 month, and 6 months after transplantation.\r\nResults: Median SAA concentrations were significantly lower in clinically stable transplant recipients than in children with acute infection (4.2 mg\/L [0.7-71.8] vs. 172 mg\/L [1.5-961], P &lt; .001). SAA concentrations \u226510 mg\/L were observed in 14% of transplant recipients and 96% of children with acute infections. In the longitudinal subgroup, SAA concentrations increased during the early postoperative period and declined toward baseline by 6 months (P = .014).\r\nConclusion: SAA concentrations were generally low in clinically stable pediatric liver transplant recipients during long-term follow-up but were substantially higher in children with acute infections. These findings provide insight into long-term SAA concentrations in this population and address an important gap in the literature.\r\nCite this article as: Aydemir S, \u00d6zden \u0130, \u00d6nal Z, Cantez S, Durmaz \u00d6. Long-term serum amyloid a profile in clinically stable pediatric liver transplant recipients. Turk J Gastroenterol. Published online September 30, 2026. doi: 10.5152\/tjg.2026.26525.<\/jats:p>","DOI":"10.5152\/tjg.2026.26525","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:51:42Z","timestamp":1790765502000},"source":"Crossref","is-referenced-by-count":0,"title":["Long-Term Serum Amyloid A Profile in Clinically Stable Pediatric Liver Transplant Recipients"],"prefix":"10.5152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5876-2601","authenticated-orcid":false,"given":"Sezin","family":"Aydemir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7360-628X","authenticated-orcid":false,"given":"\u0130lgin","family":"\u00d6zden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7627-7423","authenticated-orcid":false,"given":"Zerrin","family":"\u00d6nal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0150-912X","authenticated-orcid":false,"given":"Serdar","family":"Cantez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6969-9962","authenticated-orcid":false,"given":"\u00d6zlem","family":"Durmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2026,9,30]]},"container-title":["Turkish Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/download\/4749\/4457","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/download\/4749\/4457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:51:42Z","timestamp":1790765502000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.turkjgastroenterol.org\/index.php\/tjg\/article\/view\/4749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":0,"URL":"https:\/\/doi.org\/10.5152\/tjg.2026.26525","relation":{},"ISSN":["2148-5607"],"issn-type":[{"value":"2148-5607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]}}}